Abstract
In Darwin's Black Box: The BiochemicalChallenge to Evolution I argued thatpurposeful intelligent design, rather thanDarwinian natural selection, better explainssome aspects of the complexity that modernscience has discovered at the molecularfoundation of life. In the five years since itspublication the book has been widely discussedand has received considerable criticism. Here Irespond to what I deem to be the mostfundamental objections. In the first part ofthe article I address empirical criticismsbased on experimental studies alleging eitherthat biochemical systems I discussed are notirreducibly complex or that similar systemshave been demonstrated to be able to evolve byDarwinian processes. In the remainder of thearticle I address methodological concerns,including whether a claim of intelligent designis falsifiable and whether intelligent designis a permissible scientific conclusion.
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Behe, M.J.: 1996, Darwin's Black Box: The Biochemical Challenge to Evolution, Free Press, New York.
Behe, M.J., Dembski, W.A. and Meyer, S.: 2000, Science and Evidence for Design in the Universe, Ignatius Press, San Francisco.
Bugge, T.H., Flick, M.J., Daugherty, C.C. and Degen, J.L.: 1995, ‘Plasminogen Deficiency Causes Severe Thrombosis but Is Compatible With Development and Reproduction’, Genes and Development 9, 794–807.
Bugge, T.H., Kombrinck, K.W., Flick, M.J., Daugherty, C.C., Danton, M.J. and Degen, J.L.: 1996a, ‘Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency’, Cell 87, 709–715.
Bugge, T.H., Xiao, Q., Kombrinck, K.W., Flick, M.J., Holmback, K., Danton, M.J., Colbert, M.C., Witte, D.P., Fujikawa, K., Davie, E.W. and Degen, J.L.: 1996b, ‘Fatal Embryonic Bleeding Events in Mice Lacking Tissue Factor, the Cell-Associated Initiator of Blood Coagulation’, Proceedings of the National Academy of Sciences U.S.A. 93, 6258–6263.
Cairns-Smith, A.G.: 1985, Seven Clues to the Origin of Life: a Scientific Detective Story, Cambridge University Press, Cambridge.
Cavalier-Smith, T.: 1997, ‘The Blind Biochemist’, Trends in Ecology and Evolution 12, 162–163.
Coyne, J.A.: 1996, ‘God in the Details’, Nature 383, 227–228.
Craig, W.L. and Smith, Q.: 1993, Theism, Atheism, and Big Bang Cosmology, Clarendon Press, Oxford.
Dawkins, R.: 1986, The Blind Watchmaker, Norton, New York.
Davies, P.C.W.: 1999, The Fifth Miracle: The Search for the Origin and Meaning of Life, Simon and Schuster, New York.
Dembski, W.A.: 1998, The Design Inference: Eliminating Chance Through Small Probabilities, Cambridge University Press, Cambridge.
Denton, M.J.: 1998, Nature's Destiny: How the Laws of Biology Reveal Purpose in the Universe, Free Press, New York.
Doolittle, R.: 1997, ‘A Delicate Balance’ Boston Review Feb/March, 28–29.
Dorit, R.: 1997, ‘Molecular Evolution and Scientific Inquiry, Misperceived’, American Scientist 85, 474–475.
Flietstra, R.: 1998, ‘A Response to Michael Behe’, Books & Culture Sept/Oct, 37.
Futuyma, D.J.: 1997, ‘Miracles and Molecules’, Boston Review Feb/March, 29–30.
Guth, A.H.: 1997, The Inflationary Universe: the Quest for a New Theory of Cosmic Origins, Addison-Wesley Publishing, Reading, Mass.
Halkier, T.: 1992, Mechanisms in Blood Coagulation Fibrinolysis and the Complement System, Cambridge University Press, Cambridge.
Hall, B.G.: 1982, ‘Evolution on a Petri Dish: The Evolved ß-galactosidase System as a Model for Studying Acquisitive Evolution in the Laboratory’, in M.K. Hecht, B. Wallace and G.T. Prance (eds), Evolutionary Biology, Plenum Press, New York, pp. 85–150.
Hall, B.G.: 1999, ‘Experimental Evolution of Ebg Enzyme Provides Clues about the Evolution of Catalysis and to Evolutionary Potential’, FEMS Microbiology Letters 174, 1–8.
Maddox, J.: 1989, ‘Down With the Big Bang’, Nature 340, 425.
Miller, K.R.: 1999, Finding Darwin's God: a Scientist's Search for Common Ground Between God and Evolution, Cliff Street Books, New York.
National Academy of Sciences: 1999, Science and Creationism: a View from the National Academy of Sciences, 2nd ed, National Academy Press, Washington, DC.
Oakes, E.T.: 2001, ‘Edward T. Oakes and His critics: An Exchange’, First Things April, 5–13.
Orr, H.A.: 1996–1997, ‘Darwin V. Intelligent Design (Again)’, Boston Review Dec/Jan, 28–31.
Pennock, R.: 1999, Tower of Babel: The Evidence Against the New Creationism, MIT Press, Cambridge, MA.
Pomiankowski, A.: 1996, ‘The God of the Tiny Gaps’, New Scientist Sept. 14, 44–45.
Quill, H.: 1966, John Harrison. The Man Who Found Longitude, John Baker Publishers, London.
Ratzsch, D.: 2001, ‘Nature, Design, and Science: The Status of Design in Natural Science’, in D.E. Shaner (ed.), SUNY Series in Philosophy and Biology, State University of New York Press, Albany, New York.
Ruse, M.: 1997, ‘Enough Speculation’, Boston Review Feb/March, 31.
Ruse, M.: 1998, ‘Answering the creationists: Where they go wrong and what they're afraid of’, Free Inquiry 18, 2.
Shapiro, J.A.: 1996, ‘In the Details ... What?’, National Review Sept. 16, 62–65.
Shapiro, R.: 1999, Planetary Dreams: the Quest to Discover Life Beyond Earth, J. Wiley, New York.
Suh, T.T., Holmback, K., Jensen, N.J., Daugherty, C.C., Small, K., Simon, D.I., Potter, S. and Degen, J.L.: 1995, ‘Resolution of Spontaneous Bleeding Events but Failure of Pregnancy in Fibrinogen-deficient Mice’, Genes and Development 9, 2020–2033.
Sun, W.Y., Witte, D.P., Degen, J.L., Colbert, M.C., Burkart, M.C., Holmback, K., Xiao, Q., Bugge, T.H. and Degen, S.J.: 1998, ‘Prothrombin Deficiency Results in Embryonic and Neonatal Lethality in Mice’, Proceedings of the National Academy of Sciences U.S.A. 95, 7597–7602.
Ward, P.D. and Brownlee, D.: 2000, Rare Earth: Why Complex Life Is Uncommon in the Universe, Copernicus, New York.
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Behe, M.J. Reply to My Critics: A Response to Reviews of Darwin's Black Box: The Biochemical Challenge to Evolution. Biology & Philosophy 16, 683–707 (2001). https://doi.org/10.1023/A:1012268700496
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DOI: https://doi.org/10.1023/A:1012268700496