Anatomical abnormalities of Heschl gyrus in schizophrenia patients and unaffected relatives
Christian
Knöchel1*,
Viola
Oertel1, 2,
A.
Rotarska-Jagiel1, 2, 3,
R.
Schönmeyer1,
M.
Lindner1, 2,
V.
Van De Ven4,
C.
Haenschel1, 5,
K.
Maurer1 and
D.
E.
Linden1, 6
-
1
Neurophysiology and Neuroimaging Laboratory, Dept. of Psychiatry, Goethe University, Germany
-
2
Brain Imaging Centre, Goethe University, Germany
-
3
Dept. of Psychiatry, University of Cologne, Germany
-
4
Dept. of Neurocognition, University of Maastricht, Netherlands
-
5
Max-Planck-Institute for Brain Research, Germany
-
6
School of Psychology, University of Wales, United Kingdom
The aim of this study was to identify anatomical correlates of dysfunctional auditory areas, which may contribute to the development of auditory verbal hallucinations in schizophrenia. We did a gray matter volume analysis of the Heschl gyrus, and compared it to the psychopathological symptoms. Several studies have shown abnormalities in the temporal lobe anatomy of schizophrenic patients. However, we enlarged the study groups to examine also first-degree relatives who are rare investigated in this topic. To our knowledge, this is the first study which integrates the genetic contribution in the Heschl gyrus. The present study included three age-matched subject groups: 15 SZ patients (mean age: 41.43 [5.67]), 15 first-degree relatives (40.43 [8.74]) and 15 healthy controls (38.53 [5.23]). High-resolution 3D-anatomical MRI on a 3 TESLA SIEMENS Scanner was performed. The gray matter volume of Heschl gyrus was lower for patients than controls and intermediate for relatives. The gray matter volume loss correlated with the severity of symptoms, measured with the PANSS (Kay et al., 1987) and the Revised Hallucination Scale (RHS; Morrison et al., 2002). In addition, loss of normal hemispheric asymmetry was examined, too. These results correlated with the severity of symptoms, as shown for the volume loss. The results show that the volume loss and the loss of normal hemispheric asymmetry may be a biological marker of schizophrenia. The extent of temporal lobe abnormalities correlated with the severity of symptoms of patients.
Conference:
10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008.
Presentation Type:
Poster Presentation
Topic:
Genetics of Cognition
Citation:
Knöchel
C,
Oertel
V,
Rotarska-Jagiel
A,
Schönmeyer
R,
Lindner
M,
Van De Ven
V,
Haenschel
C,
Maurer
K and
Linden
DE
(2008). Anatomical abnormalities of Heschl gyrus in schizophrenia patients and unaffected relatives.
Conference Abstract:
10th International Conference on Cognitive Neuroscience.
doi: 10.3389/conf.neuro.09.2009.01.243
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Received:
09 Dec 2008;
Published Online:
09 Dec 2008.
*
Correspondence:
Christian Knöchel, Neurophysiology and Neuroimaging Laboratory, Dept. of Psychiatry, Goethe University, Frankfurt/Main, Germany, violaistian@gmx.de