A new scale for Frontal-Behavioral Syndrome for dementia patients: Frontal Executive Dysfunction, Disinhibition and Apathy Scale
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1
Sunkyunkwan University School of Medicine , Department of Neurology, Samsung Medical Center, Republic of Korea
Frontal lobe dysfunctions might be divided into three types (executive dysfunction, disinhibition and apathy) according to involved frontal-subcortical circuits and cortical areas. This study is to develop a new scale to assess three types of frontal-behavioral syndromes in dementia patients, called Frontal Executive dysfunctions/Disinhibition/Apathy Scale (FEDAS). A total of 357 dementia patients had participated: Alzheimer’s disease (AD, n=259), subcortical vascular dementia (SVaD, n=70), and frontotemporal lobar degeneration (FTLD, n=28). They underwent the neuropsychological tests, FEDAS, Frontal Behavioral Inventory (FBI) and Neuropsyciatric Inventory (NPI). The FEDAS is 4 points scale with 45 items and has three subscales; executive dysfunction (FEDAS-E), disinhibition (FEDAS-D) and apathy (FEDAS-A). All of the FEDAS scores significantly correlated with FBI and most of the NPI subscores except for hallucination and euphoria. The FEDAS total, FEDAS-E and FEDAS-A scores had significant correlations with most frontal/executive functions tests. The correlation between FEDAS and memory tests was not significant. Even though there was no significant deference among 3 groups on the MMSE, AD’s FEDAS total and FEDAS-A scores were significantly lower than those of FTLD. These scores did not significantly different between SVaD and FTLD. These results suggested that FEDAS could be clinically useful to assess the frontal lobes dysfunctions.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Neurologic
Citation:
Chin
J,
Na
DL,
Seo
SW and
Suh
MK
(2010). A new scale for Frontal-Behavioral Syndrome for dementia patients: Frontal Executive Dysfunction, Disinhibition and Apathy Scale.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00142
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Received:
01 Jul 2010;
Published Online:
01 Jul 2010.
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Correspondence:
J. Chin, Sunkyunkwan University School of Medicine, Department of Neurology, Samsung Medical Center, Seoul, Republic of Korea, Juheechin@gmail.com