Control of neuronal excitability by calcium binding proteins : a new mathematical model for striatal fast-spiking interneurons
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1
Université Libre de Bruxelles, Faculté de Medecine, Belgium
Calcium binding proteins, such as parvalbumin (PV), are abundantly expressed in distinctive patterns in the central nervous system but their physiological function remains poorly understood. Notably, at the level of the striatum, where PV is only expressed in the fast spiking (FS) interneurons. FS interneurons form an inhibitory network modulating the output of the striatum by synchronizing medium-sized spiny neurons (MSN). So far the existing conductance-based computational models for FS neurons did not allow the study of the coupling between PV concentration and electrical activity. In the present paper, we propose a new mathematical model for the striatal FS interneurons that includes apamin-sensitive small conductance Ca2+ -dependent K+ channels (SK) and the presence of a calcium buffer. Our results show that a variation in the concentration of PV can modulate substantially the intrinsic excitability of the FS interneurons and therefore may be involved in the information processing at the striatal level.
Acknowledgements
Laurie Lambot is supported by a doctoral fellowship from Fonds pour la formation à la Recherche dans l’Industrie et dans l’Agriculture, FRIA, Belgium. David Orduz was supported by a postdoctoral fellowship from Fonds de la Recherche Scientifique, FRS-FNRS, Belgium. This study was also supported by Fondation Médicale Reine Elisabeth (FMRE-Belgium), FRS–FNRS (Belgium), research funds from ULB and Action de Recherche Concertée from the CFWB.
Keywords:
calcium dynamics,
parvalbumin,
striatal fast-spiking interneurons,
excitability,
mathematical model
Conference:
Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012.
Presentation Type:
Poster Presentation
Topic:
Other basic/clinical neurosciences topic
Citation:
Bischop
D,
Orduz
D,
Lambot
L,
Schiffmann
SN and
Gall
D
(2012). Control of neuronal excitability by calcium binding proteins : a new mathematical model for striatal fast-spiking interneurons.
Conference Abstract:
Belgian Brain Council.
doi: 10.3389/conf.fnhum.2012.210.00008
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Received:
09 Sep 2012;
Published Online:
12 Sep 2012.
*
Correspondence:
Mr. Don Patrick Bischop, Université Libre de Bruxelles, Faculté de Medecine, Bruxelles, Belgium, dobischo@ulb.ac.be