Abstract
Living things are often plastic during their early development and are moulded by the environment. Many human fetuses have to adapt to a limited supply of nutrients, and in doing so they permanently change their physiology and metabolism. These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension.
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Barker, D.J.P.: 1995a, ‘Fetal origins of coronary heart disease’, BMJ 311, 171–174.
Barker, D.J.P.: 1995b, ‘Fetal undernutrition and adult disease’, Highlights 3, 12–15.
Barker, D.J.P.: 1998, Mothers, Babies and Health in Later Life, 2nd ed. Edinburgh: Churchill Livingstone.
Barker, D.J.P., T.W. Meade, C.H.D. Fall, A. Lee, C. Osmond, K. Phipps and Y. Stirling: 1992, ‘Relation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life’, BMJ 304, 148–152.
Bateson, P. and P. Martin: 1999, Design for a Life: How Behaviour Develops. Jonathan Cape.
Campbell, D.M., M.H. Hall, D.J.P. Barker, J. Cross, A.W. Shiell and K.M. Godfrey: 1996, ‘Diet in pregnancy and the offspring's blood pressure 40 years later’, Br J Obstet Gynaecol 103, 273–280.
Comfort, A.: 1960, ‘Nutrition and longevity in animals’, Proc Nutr Soc 19, 125–129.
Cooper, C., D. Kuh, P. Egger, M. Wadsworth and D. Barker: 1996, ‘Childhood growth and age at menarche’, Br J Obstet Gynaecol 103, 814–817.
Eriksson, J.G., T. Forsen, J. Tuomilehto, P.D. Winter, C. Osmond and D.J.P. Barker: 1999, ‘Catch–up growth in childhood and death from coronary heart disease: longitudinal study’, BMJ 318, 427–431.
Forsen, T., Eriksson, J.G., Tuomilehto, J., Osmond, C. and Barker, D.J.P.: 1999, ‘Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study’, BMJ 319, 1403–1047.
Forsen, T., J.G. Eriksson, J. Tuomilehto, K. Teramo, C. Osmond and D.J.P. Barker: 1997, ‘Mother's weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study’, BMJ 315, 837–840.
Hales, C.N. and D.J.P. Barker: 1992, ‘Type 2 (non–insulindependent) diabetes mellitus: the thrifty phenotype hypothesis’, Diabetologia 35, 595–601.
Law, C.M. and A.W. Shiell: 1996, ‘Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature’, J Hypertens 14(8), 935–941.
McCance, R.A. and E.M. Widdowson: 1974, ‘The determinants of growth and form’, Proc R Soc Lond B 185, 1–17.
Ounsted, M., A. Scott and C. Ounsted: 1986, ‘Transmission through the female line of a mechanism constraining human fetal growth’, Ann Hum Biol 13, 143–151.
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Barker, D. A new model for the origins of chronic disease. Med Health Care Philos 4, 31–35 (2001). https://doi.org/10.1023/A:1009934412988
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DOI: https://doi.org/10.1023/A:1009934412988