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Fighting the good cause: meaning, purpose, difference, and choice

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Abstract

Concepts of cause, choice, and information are closely related. A cause is a choice that can be held responsible. It is a difference that makes a difference. Information about past causes and their effects is a valuable commodity because it can be used to guide future choices. Information about criteria of choice is generated by choosing a subset from an ensemble for ‘reasons’ and has meaning for an interpreter when it is used to achieve an end. Natural selection evolves interpreters with ends. Surviving genes embody a textual record of past choices that had favorable outcomes. Consultation of these archives guides current choices. Purposive choice is well-informed difference making.

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Notes

  1. Gouyon and Gliddon (1988) wrote “any material support which allows the replication of genetic information will be termed an avatar, which is used in the Hindu religion to refer to the material forms assumed by the god Vishnu.”

  2. Representation presents again in different form, but prior forms are present again when forms recur. By this means, a thing represents its self (Hofstadter 2007; Haig 2011a).

  3. This is my footnote to Plato.

  4. My account of meaning can be viewed as parallel to Peirce’s (1877) account of belief. His trinity of belief, desire, and action—“our beliefs guide our desires and shape our actions”—can be loosely translated as my triad of meaning, end, and interpretation. For Peirce, beliefs were habits of mind that guided action: “Belief does not make us act at once, but puts us into such a condition that we shall behave in some certain way, when the occasion arises.” Represented in other words, beliefs were latent information whose meaning was expressed in conditional action to achieve a motivated end.

  5. The physician takes the role of the first assassin and cancer the role of the backup assassin in scenarios of causal preemption (e.g., Hitchcock 2007). If the patient does not die from an overdose, then the patient dies from cancer.

  6. “To the common sense of mankind it is the property of a cause, qua cause, that it might have been different and have had different effects” (Fisher 1934, p. 106).

  7. I remind readers that T at the 3’ end of the DNA segment corresponds to A at the 5’ end of the RNA segment because of antiparallel synthesis.

  8. Deleterious mutations are alternatives that are eliminated as soon as they occur. They have a phenotype but are unreasonable choices.

  9. The less-appealing traits of the suitors rejected by my mother in favor of my father comprise part of a complete causal account of how I happen to be writing this essay.

  10. This sentence deliberately confuses gene and protein. Proteins and genes often share the same name (metonymy). Sometimes a gene is named for its protein and sometimes a protein for its gene. By convention, the gene and its mRNA are italicized but not its protein. In speech, the denotation of a name often encompasses gene, mRNA, and protein.

  11. Lewontin (2000) reprises his earlier distinction between the analysis of variance and analysis of causes (Lewontin 1974).

  12. Kant (2000, p. 243) can be interpreted as making a related distinction when he describes the twofold sense in which a tree is both cause and effect of itself. A tree generates itself both as a species/genus (transmission) and as an individual (development).

References

  • Adami C (2002) What is complexity? BioEssays 24:1085–1094

    Article  Google Scholar 

  • Adami C, Ofria C, Collier TC (2000) Evolution of biological complexity. Proc Natl Acad Sci USA 97:4463–4468

    Article  Google Scholar 

  • Aristotle (1984) The complete works of Aristotle. Princeton University Press, Princeton

  • Atkins PW (1994) The second law. W. H. Freeman, New York

    Google Scholar 

  • Ayala FJ (1970) Teleological explanations in evolutionary biology. Phil Sci 37:1–15

    Article  Google Scholar 

  • Bacon F (1596) Maxims of the law

  • Bacon F (1885) The advancement of learning. In Wright WA (ed) Clarendon Press, Oxford

  • Bateson G (1972) Steps to an ecology of mind. University of Chicago Press, Chicago

    Google Scholar 

  • Bergstrom CT, Rosvall M (2011) The transmission sense of information. Biol Phil 26:159–176

    Article  Google Scholar 

  • Capurro R, Hjørland B (2003) The concept of information. Annu Rev Inform Sci Tech 37:343–411

    Article  Google Scholar 

  • Colgate SA, Ziock H (2011) A definition of information, the arrow of information, and its relationship to life. Complexity 16:54–62

    Article  Google Scholar 

  • Dawkins R (1976) The selfish gene. Oxford University Press, Oxford

    Google Scholar 

  • Dawkins R (1982) The extended phenotype. Oxford University Press, Oxford

    Google Scholar 

  • Delbrück M (1949) A physicist looks at biology. Trans Connecticut Acad Arts Sci 38:173–190

    Google Scholar 

  • Delbrück M (1971) Aristotle-totle-totle. In: Monod J, Borek E (eds) Of microbes and life. Columbia University Press, New York, pp 50–55

    Google Scholar 

  • Dennett DC (1995) Darwin’s dangerous idea. Simon and Schuster, New York

    Google Scholar 

  • Finnegan DJ (2012) Retrotransposons. Curr Biol 22:R432–R437

    Article  Google Scholar 

  • Fisher RA (1934) Indeterminism and natural selection. Phil Sci 1:99–117

    Article  Google Scholar 

  • Fisher RA (1941) Average excess and average effect of a gene substitution. Ann Eugen 11:53–63

    Article  Google Scholar 

  • Frank SA (2009) Natural selection maximizes fisher information. J Evol Biol 22:231–244

    Article  Google Scholar 

  • Frank SA (2012) Natural selection. III. Selection versus transmission and the levels of selection. J Evol Biol 25:227–243

    Article  Google Scholar 

  • Frede M (1980) The original notion of cause. In: Schofield M, Burnyeat M, Barnes J (eds) Doubt and dogmatism. Clarendon Press, Oxford, pp 217–249

    Google Scholar 

  • Gliddon CJ, Gouyon PH (1989) The units of selection. Trends Ecol Evol 4:204–208

    Article  Google Scholar 

  • Godfrey-Smith P (2009) Darwinian populations and natural selection. Oxford University Press, Oxford

    Google Scholar 

  • Gouyon PH, Gliddon C (1988) The genetics of information and the evolution of avatars. In: de Jong G (ed) Population genetics and evolution. Springer, Berlin, pp 119–123

    Chapter  Google Scholar 

  • Gregory RL (1981) Mind in science. Cambridge University Press, Cambridge

    Google Scholar 

  • Grene M (1972) Aristotle and modern biology. J Hist Ideas 33:395–424

    Article  Google Scholar 

  • Griffiths PE (2013) Lehrman’s dictum: information and explanation in developmental biology. Dev Psychobiol 55:22–32

    Article  Google Scholar 

  • Griffiths PE, Neumann-Held EM (1999) The many faces of the gene. Bioscience 49:656–662

    Article  Google Scholar 

  • Haig D (1992) Genomic imprinting and the theory of parent-offspring conflict. Semin Dev Biol 3:153–160

    Google Scholar 

  • Haig D (1997) The social gene. In: Krebs JR, Davies NB (eds) Behavioural ecology, 4th edn. Blackwell Scientific, Oxford, pp 284–304

    Google Scholar 

  • Haig D (2011a) Sympathy with Adam Smith and reflexions on self. J Econ Org Behav 77:4–13

    Article  Google Scholar 

  • Haig D (2011b) Does heritability hide in epistasis between linked SNPs? Eur J Hum Genet 19:123

    Article  Google Scholar 

  • Haig D (2012a) The strategic gene. Biol Phil 27:461–479

    Article  Google Scholar 

  • Haig D (2012b) Retroviruses and the placenta. Curr Biol 22:R609–R613

    Article  Google Scholar 

  • Haig D (2013a) Genomic vagabonds: endogenous retroviruses and placental evolution. BioEssays 35:845–846

    Google Scholar 

  • Haig D (2013b) Proximate and ultimate causes: How come? and What for? Biol Phil 28:781–786

    Article  Google Scholar 

  • Haig D, Henikoff S (2004) Deciphering the genomic palimpsest. Curr Opin Genet Dev 14:599–602

    Google Scholar 

  • Haig D, Trivers R (1995) The evolution of parental imprinting: a review of hypotheses. In: Ohlsson R, Hall K, Ritzen M (eds) Genomic imprinting: causes and consequences. Cambridge University Press, Cambridge, pp 17–28

    Google Scholar 

  • Hamilton WD (1975) Gamblers since life began: barnacles, aphids, elms. Q Rev Biol 50:175–180

    Article  Google Scholar 

  • Hanchard N, Elzein A, Trafford C, Rockett K, Pinder M et al (2007) Classical sickle beta-globin haplotypes exhibit a high degree of long-range haplotype similarity in African and Afro-Caribbean populations. BMC Genet 8:52

    Article  Google Scholar 

  • Hitchcock C (2007) Prevention, preemption, and the principle of sufficient reason. Phil Rev 116:495–532

    Article  Google Scholar 

  • Hofstadter DR (1979) Gödel, Escher, Bach. Basic Books, New York

    Google Scholar 

  • Hofstadter DR (2007) I am a strange loop. Basic Books, New York

    Google Scholar 

  • Kant I (2000) Critique of the power of judgment (trans: Guyer P, Matthews E). Cambridge University Press, Cambridge

  • Laland KN, Odling-Smee J, Hoppitt W, Uller T (2013a) More of how and why: cause and effect in biology revisited. Biol Phil 28:719–745

    Article  Google Scholar 

  • Laland KN, Odling-Smee J, Hoppitt W, Uller T (2013b) More of how and why: a response to commentaries. Biol Phil 28:793–810

    Article  Google Scholar 

  • Lewis D (2000) Causation as influence. J Phil 97:182–197

    Article  Google Scholar 

  • Lewontin RC (1974) The analysis of variance and the analysis of causes. Am J Hum Genet 26:400–411

    Google Scholar 

  • Lewontin RC (2000) Foreword. In: Oyama S (ed) The ontogeny of information, 2nd edn. Duke University Press, Durham, NC, pp vii–xv

  • Mellor J (2005) The dynamics of chromatin remodeling at promoters. Mol Cell 19:147–157

    Article  Google Scholar 

  • Moffatt B (2011) Conflations in the causal account of information undermine the parity thesis. Phil Sci 78:284–302

    Article  Google Scholar 

  • Nash O (1936) The bad parents’ book of verse. Simon and Schuster, New York

    Google Scholar 

  • Neher RA, Shraiman BI (2009) Competition between recombination and epistasis can cause a transition from allele to genotype selection. Proc Natl Acad Sci USA 106:6866–6871

    Article  Google Scholar 

  • Neher RA, Kessinger TA, Shraiman BI (2013) Coalescence and genetic diversity in sexual populations under selection. Proc Natl Acad Sci USA 110:15836–15841

    Article  Google Scholar 

  • Okasha S (2012) Social justice, genomic justice and the veil of ignorance: Harsanyi meets Mendel. Econ Phil 28:43–71

    Article  Google Scholar 

  • Oyama S (2000) The ontogeny of information. Developmental systems and evolution, 2nd edn. Duke University Press, Durham

  • Pearson L (1952) Prophasis and aitia. Trans Proc Am Philol Assoc 83:203–223

    Google Scholar 

  • Peirce CS (1877) Illustrations of the logic of science. First paper. The fixation of belief. Pop Sci Mon 12:1–15

    Google Scholar 

  • Peirce CS (1905) What pragmaticism is. Monist 15:161–181. (title corrected)

    Google Scholar 

  • Pittendrigh CS (1961) On temporal organization in living systems. Harvey Lect 56:93–125

    Google Scholar 

  • Pittendrigh CS (1993) Temporal organization: reflections of a Darwinian clock-watcher. Annu Rev Physiol 55:17–54

    Article  Google Scholar 

  • Price GR (1995) The nature of selection. J Theor Biol 175:389–396

    Article  Google Scholar 

  • Ridley M (2000) Mendel’s demon. Weidenfeld and Nicholson, London

    Google Scholar 

  • Russell B (1913) On the notion of cause. Proc Aristot Soc 13:1–26

    Google Scholar 

  • Sartorio C (2005) Causes as difference makers. Phil Stud 123:71–96

    Article  Google Scholar 

  • Shea N (2007) Representation in the genome and in other inheritance systems. Biol Phil 22:313–331

    Article  Google Scholar 

  • Sterne L (1767) The life and opinions of Tristram Shandy, gentleman

  • Tennyson A (1849) In memoriam. AHH

  • Weismann A (1890) Prof. Weismann’s theory of heredity. Nature 41:317–323

    Article  Google Scholar 

  • Williams GC (1966) Adaptation and natural selection. Princeton University Press, Princeton

    Google Scholar 

  • Williams GC (1992) Natural selection. Domains, levels, and challenges. Oxford University Press, Oxford

  • Winnie JA (2000) Information and structure in molecular biology: comments on Maynard Smith. Phil Sci 67:517–526

    Article  Google Scholar 

Download references

Acknowledgments

Daniel Dennett, Jeffrey Lipshaw, Eric Schliesser, James Simpson, Kim Sterelny, Wenfei Tong, and Adrian Young contributed to the manuscript. Samir Okasha is to blame but the credit is mine. Thanks to the Arnold Arboretum under snow for inspiration and the Colloquium on the Fundamental Interconnectedness of All Things for special effects. Particular thanks to the many unacknowledged influences without whom it would not have been written in quite the way it was. In memory of David Haig (1932–2012).

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Haig, D. Fighting the good cause: meaning, purpose, difference, and choice. Biol Philos 29, 675–697 (2014). https://doi.org/10.1007/s10539-014-9432-4

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