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From Virus Research to Molecular Biology: Tobacco Mosaic Virus in Germany, 1936-1956

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Abstract

In 1937, a group of researchers in Nazi Germany began investigating tobaccomosaic virus (TMV) with the hope of using the virus as a model system for understandinggene behavior in higher organisms. They soon developed a creative and interdisciplinarywork style and were able to continue their research in the postwar era, when they madesignificant contributions to the history of molecular biology. This group is significant fortwo major reasons. First, it provides an example of how researchers were able to produceexcellent scientific research in the midst of dictatorship and war. Coupled with the group'songoing success in postwar Germany, the German TMV investigators provide a dramaticexample of how scientific communities deal with adversity as well as rapid political and socialchange. Second, since the researchers focused heavily (though not exclusively) on TMV, theirstory allows us to analyze how an experimental system other than phage contributed to theemergence of molecular biology.

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Lewis, J. From Virus Research to Molecular Biology: Tobacco Mosaic Virus in Germany, 1936-1956. Journal of the History of Biology 37, 259–301 (2004). https://doi.org/10.1023/B:HIST.0000038206.09052.7a

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