Abstract
Twenty adult male Sprague-Dawley rats were fixed with a chronically indwelling electrode for intracranial stimulation (ICS) of the lateral hypothalamus. Subsequently, rats pressed daily for four intensities of ICS, 2 min at each intensity. Subsequent to establishment of baseline pressing rates, rats were administered doses of amphetamine of 0,.5, or 4 mg/kg for 26 days. Opportunities to press for ICS were given.5 and 23 h after injections. Following days of injections, there were further tests spanning 12 days. Initially, during the tests.5 h after injections, the smaller dose of amphetamine slightly increased pressing over baseline and pressing of rats of 0 mg/kg. Across days of injections the shift in pressing under the smaller dose was stable. Initially, the larger doses decreased pressing.5 h after injections; however, across days of injections pressing increased to near baseline levels though never exceeding them. There were no discernible effects on pressing with tests 23 h after injections. Following the 26-day regimen of injections and testing, all press rates were at baseline levels.
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Obaldia, R.D., Magnuson, D.J. & Reid, L.D. Addictive agents and intracranial stimulation:Daily amphetamine and hypothalamic self-stimulation. Bull. Psychon. Soc. 9, 377–379 (1977). https://doi.org/10.3758/BF03337028
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DOI: https://doi.org/10.3758/BF03337028