A simple auditory event-related potential is linked to cerebral grey matter pathology in schizophrenia
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1
University of Newcastle, Australia
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2
Schizophrenia Research Institute, Australia
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3
University of California Los Angeles, United States
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4
University of New South Wales, Australia
‘Mismatch negativity’ (MMN) amplitude reduction is well established in schizophrenia. MMN is an auditory event-related response (ERP) to an infrequent discriminable change in repetitive background sounds. It is derived by subtracting the ERP to a frequent standard stimulus from the ERP to an infrequent deviant stimulus. Here we investigate the relationship of MMN and cortical grey matter in schizophrenia. MMN and structural magnetic resonance images (sMRI) were collected from 18 schizophrenia subjects and 18 pair-wise age- and gender-matched healthy control subjects. MMN peak amplitudes were determined within 100 to 300 msec post-stimulus intervals for three types of deviant stimuli that differed from the standard in duration, frequency and intensity. For the structural analysis, models were extracted from the sMRI of all subjects followed by the identification and tracing of sulcal landmarks. Average models of the cerebral cortex were generated using cortical pattern matching; a technique that maintains the relationship with the individual’s scan while allowing the accurate averaging of gyral structures across subjects. Correlation maps (p < .05) of cerebral grey matter with peak amplitudes for each MMN type were calculated and tested by permutation analysis. Grey matter reduction in cortical areas subserving auditory processing, motor organization and executive function correlated with reduced MMN amplitude in patients to frequency deviants only. No correlations were observed in healthy controls. These results suggest that frequency MMN amplitude reduction in schizophrenia reflects progressive loss of grey matter volume whereas duration and intensity MMN amplitude reductions that are evident early in the illness may precede cell loss. Funding: Funded by the Commonwealth of Australia through the National Health & Medical Research Council.
Keywords:
Grey Matter,
Neuropsychiatry
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Neuropsychiatric Applications
Citation:
Schall
U,
Rasser
P,
Todd
J,
Thompson
P and
Ward
P
(2011). A simple auditory event-related potential is linked to cerebral grey matter pathology in schizophrenia.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00114
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Received:
17 Nov 2011;
Published Online:
25 Nov 2011.
*
Correspondence:
Dr. Ulrich Schall, University of Newcastle, Newcastle, Australia, ulrich.schall@newcastle.edu.au