Replay of movie-driven correlation structures in human cortex during sleep
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1
Hebrew University of Jerusalem, Israel
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2
Weizmann Institute of Science, Israel
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3
EEG and Epilepsy Unit & Functional Neurosurgery Unit, Tel Aviv Medical Center, Israel
The link between conscious awareness and perception and brain activity is one of the fundamental questions occupying neuroscientists today. It would seem that sleep, with the altered states of consciousness which it entails, would provide an excellent framework for studying this question. In recent years studies have shown altered processing of external stimuli during sleep, as well as reactivation, in animal models, of cortical patterns during both REM and Slow Wave Sleep (SWS). Here we used electrocorticography (ECoG) recordings from 480 electrodes from 8 patients with intractable epilepsy, who were undergoing approximately a week of invasive monitoring with implanted grids of subdural electrodes, for strictly clinical purposes. We examined the correlation structure (also termed functional connectivity) patterns of ECoG signal modulations during different sleep stages with those obtained while the patients were awake watching two repeats of a movie segment. Our results show a robust and highly significant “replay” of the movie induced pattern during sleep. The level of similarity between the movie induced and sleep patterns fluctuated during sleep, ranging from a minimum of 0.03 to a maximum 0.52. Relating the fluctuations to transitions between different sleep states revealed complex interactions between the sleep stages and replay. For example, moments where the replay of movie-driven correlation pattern was most robust occurred both during the deepest SWS, and during REM. These findings indicate that during sleep functional networks co-activate in a similar manner to that induced by rich sensory stimulation. This reactivation might offer a substrate for both sensory dream experience and memory consolidation, or homeostatic upkeep of synapses. Funding: US-Israel BSF to R. M and I. Fried. and by ISF, Bikura, and Mark Scher’s estate grants to R. M, and ICNC and Golda Meir scholarships to M. R.
Keywords:
Awareness,
ECoG
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Consciousness and Awareness
Citation:
Ramot
M,
Fisch
L,
Davidesco
I,
Harel
M,
Kipperwasser
S,
Andelman
F,
Neufeld
MY,
Kramer
U,
Fried
I and
Malach
R
(2011). Replay of movie-driven correlation structures in human cortex during sleep.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00055
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Received:
15 Nov 2011;
Published Online:
25 Nov 2011.
*
Correspondence:
Dr. Michal Ramot, Hebrew University of Jerusalem, Jerusalem, Israel, mramot@gmail.com