Abstract
Standard laboratory rats were maintained on a daily regimen involving 22 h of deprivation of fluids followed by a 2-h opportunity to take water and a sweetened alcoholic beverage. The rats initially took very little of the alcoholic beverage, but after about 3 or 4 weeks they were taking about 2.0–2.5 g/kg of ethanol daily. This level of intake remained stable across subsequent daily opportunities. On the 37th day of the regimen, all subjects received a placebo prior to the opportunity to take fluids. On the next 2 days, the rats received 0, 1, 3, 10, or 30 mg of ACTH4-10 prior to the drinking session. No dose of ACTH4-10 reliably modified the rats’ intakes of the alcoholic beverage or water. This is in contrast with the report of Krishnan, Nash, and Maikel (1991) that 30 μ of ACTH4-10, given daily, reliably reduced 24-h intake of alcohol across an 8-day period.
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These procedures were supported by a gift from Biomeasure Incorporated and by Grant DAO4440 from the National Institute on Drug Abuse.
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Reid, L.D., Amendola, C.A., Delong, C.L. et al. The effects of ACTH4-10 on rats’ intakes of a sweetened alcoholic beverage. Bull. Psychon. Soc. 30, 411–413 (1992). https://doi.org/10.3758/BF03334103
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DOI: https://doi.org/10.3758/BF03334103