Abstract
Rats were given one of three doses of angiotensin-II to induce drinking. These same subjects were also given one of five doses of naloxone (.0,.1, 1.0, 5.0, or 10 mg/kg, sc) 15 min before an opportunity to drink for 1 h. Subjects receiving.0 mg/kg of naloxone and angiotensin drank about 6.0 g of water, whereas subjects receiving 1.0, 5.0, and 10 mg/kg of naloxone and angiotensin took only about 1.0 g of water. Naloxone clearly suppressed angiotensin-induced drinking. This finding adds further support to the hypothesis that there is an endorphinergic component in the system regulating drinking.
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Rowland, N. Inhibition of drinking in rats by naloxone: Dose-response comparisons between osmotic, volumetric, and angiotensin stimuli. Manuscript submitted for publication, 1981.
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The research was supported, in part, by a grant from the National Science Foundation (BNS 78-17860). We thank Endo Laboratories for supplying naloxone.
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Siviy, S.M., Rockwood, G.A. & Reid, L.D. Naloxone and angiotensin-II-induced drinking. Bull. Psychon. Soc. 17, 273–274 (1981). https://doi.org/10.3758/BF03333738
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DOI: https://doi.org/10.3758/BF03333738