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The challenge of identifying cellular mechanisms of memory formation during sleep

Published online by Cambridge University Press:  19 July 2005

Ronald Szymusiak*
Affiliation:
Research Service (151A3), V.A. Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343

Abstract

Cellular mechanisms hypothesized to underlie sleep-dependent memory consolidation are expressed throughout the brain during sleep. Use of sleep deprivation to evaluate the functional importance of these mechanisms is confounded by degradation in waking performance resulting from impaired vigilance. There is a need for methods that will permit disruption of specific mechanisms during sleep only in the neuronal circuits most critically involved in learning. This should be accomplished without global sleep disruption and with preservation of the restorative aspects of sleep.

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 2005

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