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The Pathogenesis of Alzheimer’s Disease. What Causes Dementia?

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Book cover Neurophilosophy and Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Summary

Despite a long held theory citing plaques and tangles as the proposed cause of dementia, available data seem to refute this view statistically. On the other hand, synaptic density in association cortex correlates very strongly with dementia scores, and it is the loss of cortical synapses which we propose to be the immediate or proximate cause of dementia in Alzheimer’s disease.

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Authors
  1. R. D. Terry
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Editors and Affiliations

  1. Fondation IPSEN pour la Recherche Thérapeutique, 30, rue Cambronne, F-75737, Paris Cedex, France

    Yves Christen Ph.D.

  2. Department of Philosophy, University of California, 92093, La Jolla, CA, USA

    Patricia S. Churchland

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© 1992 Springer-Verlag Berlin Heidelberg

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Terry, R.D. (1992). The Pathogenesis of Alzheimer’s Disease. What Causes Dementia?. In: Christen, Y., Churchland, P.S. (eds) Neurophilosophy and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46759-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-46759-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46761-5

  • Online ISBN: 978-3-642-46759-2

  • eBook Packages: Springer Book Archive

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