Abstract
This study explored the feasibility of using the probability and strength of elicited audiogenic seizures for assessing the severity of the withdrawal state of alcohol-addicted rats at various points in alcohol withdrawal. Results indicate that both seizure probability and seizure strength vary systematically and appropriately with time in withdrawal, with duration of prior alcoholization, and with diazepam treatment, but they are independent of the number of prior seizure tests that have been administered to a particular subject.
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This research was supported in part by a grant from the graduate school of the University of Minnesota and NICHHD Grant HD01136 to the Center for Research in Human Learning, University of Minnesota.
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Trapold, M.A., Sullivan, H.L. Assessment of the ethanol withdrawal state in the rat by means of repeatedly elicited audiogenic seizures. Bull. Psychon. Soc. 14, 301–303 (1979). https://doi.org/10.3758/BF03329461
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DOI: https://doi.org/10.3758/BF03329461