Abstract
How can new drug lead suggestions beinferred from neurophysiological models? This paperaddresses this question based on a case study ofresearch into Parkinson's disease at the GroningenUniversity Department of Pharmacy. It is argued thatneurophysiological box-and-arrow models can beunderstood as qualitative differential equationmodels. An inference task is defined to helpunderstand and possibly aid the discovery andexplanation of new drug lead suggestions.
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van den Bosch, A.P. Inference to the Best Manipulation – A Case Study of Qualitative Reasoning in Neuropharmacy. Foundations of Science 4, 483–495 (1999). https://doi.org/10.1023/A:1009652019363
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DOI: https://doi.org/10.1023/A:1009652019363