Abstract
Naloxone reduces fluid consumption in rats. It also produces a conditioned taste aversion (CTA). No reliable correlation was found between these two measures, suggesting that the reductions in drinking are unrelated to the illness-producing effects indexed by the CTA test. Measures of CTA using naloxone were also uncorrelated with measures of voluntary oral consumption of sweetened morphine solutions. In addition, naloxone suppression of drinking was unaffected by prior morphine administration with the administration of morphine given in a variety of ways, including dependence-producing regimens of injections.
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Coogle, C. L. Naloxone and morphine effects on electrical self-stimulation of the accumbens nucleus in addict and nonaddict rats. Unpublished master’s thesis, Rensselaer Polytechnic Institute, 1979.
Frenk, H., & Rogers, G. H. The suppressant effects of naloxone on food and water intake in the rat. Behavioral and Neural Biology, 1979, 26, 23-40.
Gorman, J. E., DeObaldia, R. N., Scott, R. C., & Reid, L. D. Morphine injections in the taste aversion paradigm: Extent of aversions and readiness to consume sweetened morphine solutions. Physiological Psychology, 1978, 6, 101–109.
Holtzman, S. G. Effects of narcotic antagonists on fluid intake in the rat. Life Sciences, 1975, 16, 1465–1470.
Holtzman, S. G. Suppression of appetitive behavior in the rat by naloxone: Lack of effect of prior morphine dependence. Life Sciences, 1979, 24, 219–226.
LeBlanc, A. E., & Cappell, H. Antagonism of morphine-induced aversive conditioning by naloxone. Pharmacology, Biochemistry and Behavior, 1975, 3, 185–188.
Stapleton, J. M., Lind, M. D., Merriman, V. J., Bozarth, M. A., & Reid, L. D. Affective consequences and subsequent effects on morphine self-administration of d-ala2-methionine enkephalin. Physiological Psychology, 1979, 7, 146–152.
Stapleton, J. M., Ostrowski, N. L., Merriman, V. J., Lind, M. D., & Reid, L. D. Naloxone reduces fluid consumption in water-deprived and nondeprived rats. Bulletin of the Psychonomic Society, 1979, 13, 237–239.
Stolerman, I. P., Pilcher, C. W. T., & D’Mello, G. D. Stereospecific aversive property of narcotic antagonists in morphine-free rats. Life Sciences, 1978, 22, 1755–1762.
Van Der Kooy, D., & Phillips, A. G. Temporal analysis of naloxone attenuation of morphine-induced taste aversion. Pharmacology, Biochemistry and Behavior, 1977, 6, 637–641. (Received for publication July 25, 1979.)
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This work was supported by Grants MH/DA 31987 and BNS 78-17860 to Ralph G. Noble, principal investigator. S. E. Cruz-Morales is on leave from the Universidad Nacional Autónoma de México y becario de CONACYT. Department of Psychology, University of California at Los Angeles. Naloxone hydrochloride was provided courtesy of Endo Laboratories.
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Wu, MF., Cruz-Morales, S.E., Quinan, J.R. et al. Naloxone reduces fluid consumption: Relationship of this effect to conditioned taste aversion and morphine dependence. Bull. Psychon. Soc. 14, 323–325 (1979). https://doi.org/10.3758/BF03329467
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DOI: https://doi.org/10.3758/BF03329467