Bryan Maloney Indiana University Purdue University, Indianapolis
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  1. Debomoy K. Lahiri, Bryan Maloney & Nasser H. Zawia (2009). The LEARn Model: An Epigenetic Explanation for Idiopathic Neurobiological Diseases. Molecular Psychiatry 14 (11):992-1003.
    Neurobiological disorders have diverse manifestations and symptomology. Neurodegenerative disorders, such as Alzheimer's disease, manifest late in life and are characterized by, among other symptoms, progressive loss of synaptic markers. Developmental disorders, such as autism spectrum, appear in childhood. Neuropsychiatric and affective disorders, such as schizophrenia and major depressive disorder, respectively, have broad ranges of age of onset and symptoms. However, all share uncertain etiologies, with opaque relationships between genes and environment. We propose a 'Latent Early-life Associated Regulation' (LEARn) model, positing (...)
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