Online research in philosophy

"Standing on the shoulders of giants." This metaphorical description of scientific and technological progress is stamped on one edge of the British £2 coin as it is in circulation today. The history of ideas tells us that the exact literal formulation is Newton's, but the metaphor goes back to Scholastic thinkers and became widely spread during the following centuries. Francis Bacon's image of science was radically different. To him research meant leaving aside traditional views and starting in a radically new (...) way. This idea is illustrated on the title page of his main work, the Novum Organum, which displays the picture of a sailing ship passing through the Pillars of Hercules (symbolizing the borders of the .. (shrink)

In Goethe's Faust, the poet refers to alchemists' widespread ideas on artificial creation of life in the laboratory. In Faust, such an attempt was not successful: the little man,Homunculus, created by the scholar Wagner through crystallization, was a pure spirit; his form and light disappeared in an attempt to become real life. According to Goethe, life was obviously not a crystal, and he pointed to decisive differences between crystals and organic beings, the latter for example elaborating their food into clear-cut (...) organs and unable to be reconstituted from their ingredients, once destroyed. Thus Goethe's "sensitivity to the 'Gestalt' of the entire complicated organism and his general philosophical attitude .. (shrink)

In this second decade of the 21st century, we find the pervasive influence of synthetic biology everywhere, not only in research laboratories, but also in the discourses of politicians and ethicists. Despite its ubiquity, the precise meaning of the notions of "synthetic biology" and "synthetic life," as well as their history, potential, and risks, remain obscure not only to the layperson, but also to most biologists.The aim of this special issue is twofold. First, it is intended to help the reader (...) better appreciate what synthetic biology is all about and what are its roots. Second, once the overall picture has been expounded and made clearer, the questions of whether research in synthetic biology raises new and .. (shrink)

The topic of synthetic life has long been a subject for science fiction writers, philosophers, and even scientists. With the announcement in 2010 by renowned biologist J. Craig Venter that he and a team of scientists from the J. Craig Venter Institute (JCVI) had created a bacterial cell with chemically synthesized genome, discussions of synthetic life were no longer just conjecture.Humans had assembled nonliving components to make a living cell (Gibson et al. 2010). I was one of the leaders of (...) that endeavor, and this article will be a first-person account of how we made our cell, along with my conjectures about what will come next in the new fields of synthetic biology and synthetic genomics.Scanning electron .. (shrink)

To illustrate dramatically the progress and potential in the field of synthetic biology, one can begin the story with the 2011 winner of the Lasker Clinical Medical Research Award (Youyou 2011). She was an 81-year-old Chinese scientist, Dr. Tu Youyou, who was given an assignment in 1969 by the Chinese government to find a treatment for malaria from among Chinese herbal medicines. She investigated more than 2,000 Chinese herbal preparations, winnowed them down to some 640 possibilities, obtained 380 extracts from (...) about 200 Chinese herbs, and tested them against a mouse model of malaria. She found one extract, of the Artemisia plant, effective in mice, but she could not reproduce the results consistently. So she .. (shrink)

This article opens with a disclaimer: I am not a scientist, and the science of synthetic biology is beyond my comprehension. I am a philosopher and an ethicist interested in moral issues in reproductive medicine. In my past research I have raised theoretical questions about the normative constraints on the creation of human beings, especially in the context of the debates on genetic screening and genetic engineering, on both the individual level and the collective, namely that pertaining to the intervention (...) in the human genome.Moral norms usually apply to our relations with other human beings. The questions of reproductive medicine are problematic, since although they relate to human beings, these human beings are .. (shrink)

The aim of synthetic biology is to rationally design devices, systems, and organisms with desired innovative and useful functions (Slusarczyk, Lin, and Weiss 2012). To achieve this aim, synthetic biology uses a concept similar to engineering sciences: well-characterized and standardized modular biological building blocks are reassembled in a systematic and rational manner to generate complex devices and systems with a predicted function. In the past, molecular biological research in combination with intense work in new research areas like systems biology and (...) functional genomics revealed a large inventory of multifaceted modular biological parts that are now in the toolboxes of synthetic biologists. Due to .. (shrink)

The integration of computer science, biology, and engineering has resulted in the emergence of rapidly growing interdisciplinary fields such as bioinformatics, bioengineering, DNA computing, and systems and synthetic biology. Ideas derived from computer science and engineering can provide innovative solutions to biological problems and advance research in new directions. Although interdisciplinary research has become increasingly prevalent in recent years, the scientists contributing to these efforts largely remain specialists in their original disciplines and are not fully capable of covering the many (...) facets of multidisciplinary problems, which impedes the development of truly integrated solutions. It would be .. (shrink)

The construction of synthetic life might appear to be the natural objective of the emerging discipline of synthetic biology. The situation, though, is not that simple. Plans to synthesize life appeared quite early, at the beginning of the 20th century (Bensaude-Vincent 2009; Deichmann 2009; Fox Keller 2002; Pereto and Catala 2007). Nor can synthetic biology be identified with work on the origin of life. Nevertheless, it is remarkable that a new, more integrated approach to the origin of life appeared exactly (...) when synthetic biology was emerging (Szostak, Bartel, and Luisi 2001).Most synthetic biologists have the more limited ambition of modifying existing organisms by giving them new functionalities. Synthetic .. (shrink)

On behalf of the editors of Perspectives in Biology and Medicine, I am pleased to introduce the editors and venue of the Symposium on Synthetic Life: Scientific, Historical, and Ethical Perspectives, which occupies much of the current issue of our journal. We are very pleased that Professors Ute Deichmann, Michel Morange, and Anthony S. Travis planned, organized, and edited the proceedings of the workshop on this topic, held on March 5-6, 2012, at the Jacques Loeb Centre for the History and (...) Philosophy of the Life Sciences and the NIBN at Ben-Gurion University of the Negev in Beer Sheva, Israel.Professor Deichmann has been the founding director of the Centre since it was created in 2007. Although she trained in .. (shrink)