Hyperstructures, genome analysis and I-cells

Acta Biotheoretica 50 (4):357-373 (2002)
  Copy   BIBTEX

Abstract

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology.

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 90,221

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Hypercomplexity.Vic Norris, Armelle Cabin & Abdallah Zemirline - 2005 - Acta Biotheoretica 53 (4):313-330.
Hyperstructures, topology and datasets.Nils A. Baas - 2009 - Axiomathes 19 (3):281-295.

Analytics

Added to PP
2009-01-28

Downloads
76 (#197,906)

6 months
2 (#658,980)

Historical graph of downloads
How can I increase my downloads?

Citations of this work

Hypercomplexity.Vic Norris, Armelle Cabin & Abdallah Zemirline - 2005 - Acta Biotheoretica 53 (4):313-330.

Add more citations

References found in this work

No references found.

Add more references