David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Patrick Amar, Pascal Ballet, Georgia Barlovatz-Meimon, Arndt Benecke, Gilles Bernot, Yves Bouligand, Paul Bourguine, Franck Delaplace, Jean-Marc Delosme, Maurice Demarty, Itzhak Fishov, Jean Fourmentin-Guilbert, Joe Fralick, Jean-Louis Giavitto, Bernard Gleyse, Christophe Godin, Roberto Incitti, François Képès, Catherine Lange, Lois Le Sceller, Corinne Loutellier, Olivier Michel, Franck Molina, Chantal Monnier, René Natowicz, Vic Norris, Nicole Orange, Helene Pollard, Derek Raine, Camille Ripoll, Josette Rouviere-Yaniv, Milton Saier, Paul Soler, Pierre Tambourin, Michel Thellier, Philippe Tracqui, Dave Ussery, Jean-Claude Vincent, Jean-Pierre Vannier, Philippa Wiggins & Abdallah Zemirline
Acta Biotheoretica 50 (4):357-373 (2002)
New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology.
|Keywords||Philosophy Philosophy of Biology Evolutionary Biology|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
D. Manoussaki, S. R. Lubkin, R. B. Vemon & J. D. Murray (1996). A Mechanical Model for the Formation of Vascular Networks in Vitro. Acta Biotheoretica 44 (3-4):271-282.
Caroline Rosello, Pascal Ballet, Emmanuelle Planus & Philippe Tracqui (2004). Model Driven Quantification of Individual and Collective Cell Migration. Acta Biotheoretica 52 (4):343-363.
Philippe Tracqui & Jacques Ohayon (2004). Transmission of Mechanical Stresses Within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model. Acta Biotheoretica 52 (4):323-341.
François Leitner, Sylvain Paillasson, Xavier Ronot & Jacques Demongeot (1995). Dynamic Functional and Structural Analysis of Living Cells: New Tools for Vital Staining of Nuclear DNA and for Characterisation of Cell Motion. Acta Biotheoretica 43 (4):299-317.
Vic Norris, Armelle Cabin & Abdallah Zemirline (2005). Hypercomplexity. Acta Biotheoretica 53 (4):313-330.
José Pierrez & Xavier Ronot (1992). Flow Cytometric Analysis of the Cell Cycle: Mathematical Modeling and Biological Interpretation. Acta Biotheoretica 40 (2-3):131-137.
Nils A. Baas (2009). Extended Memory Evolutive Systems in a Hyperstructure Context. Axiomathes 19 (2):215-221.
Pierre Auger, Peter Dörmer & Joachim W. Ellwart (1992). Growth Factors and Cell Kinetics: A Mathematical Model Applied to Il-3 Deprivation on Leukemic Cell Lines. Acta Biotheoretica 40 (2-3):147-159.
Nils A. Baas (2009). Hyperstructures, Topology and Datasets. Axiomathes 19 (3):281-295.
Added to index2009-01-28
Total downloads20 ( #124,262 of 1,696,808 )
Recent downloads (6 months)9 ( #64,794 of 1,696,808 )
How can I increase my downloads?