Disturbances of conscious in dementia with Lewy bodies assocated with alterantion in nicotonic receoptor binding in the temporal cortex

Consciousness and Cognition 11 (3):461-474 (2002)
Disturbances of consciousness, including fluctuations in attention and awareness, are a common and clinically important symptom in dementia with Lewy bodies . In the present study we investigate potential mechanisms of such disturbances of consciousness in a clinicopathological study evaluating specific components of the cholinergic system. [3H]Epibatidine binding to the high-affinity nicotinic receptor in the temporal cortex differentiated DLB cases with and without DOC, being 62–66% higher in those with DOC . The were no differences between DLB patients with or without DOC in 125I-labeled α-bungaratoxin binding to the low-affinity nicotinic receptor, [3H]pirenzepine binding to the muscarinic M1 receptor, or in choline acetyltransferase activity. These findings provide support for the hypothesis that cholinergic activity is an important neural correlate if consciousness and suggest a mechanism of DOC in DLB involving alterations in the nicotinic receptor, composed of predominantly α4 and β2 subunits
Keywords *Consciousness Disturbances  *Dementia with Lewy Bodies  *Neural Receptors  *Receptor Binding  *Temporal Lobe  Choline  Cholinergic Receptors  Neurology  Neuropathology  Nicotine  Physiological Correlates
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DOI 10.1016/S1053-8100(02)00013-2
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J. E. Tomberg Desmedt (1995). Consciousness. Electroencephalography and Clinical Neurophysiology, Supplement 44:227-34.

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M. Walker & Elaine Perry (2002). Dementia with Lewy Bodies: A Disorder of Consciousness? In Elaine Perry, Heather Ashton & Andrew W. Young (eds.), Neurochemistry of Consciousness. John Benjamins 36--263.

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