Effect of myocardial infarction and ischemia on induction of cardiac reentries and ventricular fibrillation
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Alain L. Bardou, Pierre M. Auger, Soumeya Achour, Philippe Dumee, Pierre J. Birkui & Marie-Claude Govaere
Acta Biotheoretica 43 (4) (1995)
The present work is aimed at investigating the effects of myocardial infarction and ischemia on induction of ventricular fibrillation. Electrophysiologic effects of global and local ischemia (variation of the dispersion of refractory periods as well as conduction velocity) on initiation of reentry mechanisms was studied by means of computer simulations based on a cellular automata model of propagation of activation wave through a ventricular surface element. A local area of ischemia where effects of the dispersion of refractory periods are investigated is then simulated. This is made using a Gaussian distribution characterized by its mean and standard deviation. These simulations show that ischemia is capable of initiating reentry phenomena which propagate through the whole ventricle; they are responsible for ventricular fibrillation which causes sudden cardiac death, even when ischemia only involves limited parts of the myocardium. Statistical study of the probability of reentries as a function of both of the size of ischemic zones and the rate of dispersion of refractory periods shows that the latter parameter is of primary importance in triggering cardiac reentries
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Audrey Pustoc'H., Jacques Ohayon, Yves Usson, Alain Kamgoue & Philippe Tracqui (2005). An Integrative Model of the Self-Sustained Oscillating Contractions of Cardiac Myocytes. Acta Biotheoretica 53 (4).
Anne Gammelgaard (2004). Informed Consent in Acute Myocardial Infarction Research. Journal of Medicine and Philosophy 29 (4):417 – 434.
V. Le Rolle, A. I. Hernandez, P. Y. Richard, J. Buisson & G. Carrault (2005). A Bond Graph Model of the Cardiovascular System. Acta Biotheoretica 53 (4).
H. Bettermann & P. Leeuwen (1992). Dimensional Analysis of RR Dynamic in 24 Hour Electrocardiograms. Acta Biotheoretica 40 (4).
A. Defontaine, A. Hernández & G. Carrault (2004). Multi-Formalism Modelling and Simulation: Application to Cardiac Modelling. Acta Biotheoretica 52 (4).
Jean-Pierre Boissel (2010). In Silico Study of the Influence of Intensity and Duration of Blood Flow Reduction on Cell Death Through Necrosis or Apoptosis During Acute Ischemic Stroke. Acta Biotheoretica 58 (2):171-190.
P. Auger, R. Cardinal, A. Bril, L. Rochette & A. Bardou (1992). Interpretation of Epicardial Mapping by Means of Computer Simulations: Applications to Calcium, Lidocaine and to BRL 34915. Acta Biotheoretica 40 (2-3).
R. G. Seigneuric, J.-L. Chassé, P. Auger & A. Bardou (2005). Simulated Interactions Between a Class III Antiarrhythmic Drug and a Figure 8 Reentry. Acta Biotheoretica 53 (4).
A. L. Bardou, R. G. Seigneuric, J.-L. Chassé & P. M. Auger (1999). Incidence of Dispersion of Refractoriness and Cellular Coupling Resistance on Cardiac Reentries and Ventricular Fibrillation. Acta Biotheoretica 47 (3-4).
Sorry, there are not enough data points to plot this chart.
Added to index2009-01-28
Total downloads1 ( #446,287 of 1,102,935 )
Recent downloads (6 months)1 ( #297,435 of 1,102,935 )
How can I increase my downloads?