Theoretical study of cardiac transient conduction blocks on reentries induction. Applications to antiarrhythmic drugs
Acta Biotheoretica 45 (3-4) (1997)
|Abstract||Limitations of antiarrhythmic drugs on cardiac sudden death prevention appeared since the early 80's. The "Cardiac Arrhythmia Suppression Trial"(CAST) showed more recently that mortality was significantly higher inpatients treated with some particular antiarrhythmic drugs than in non-treated patients. In this field, our group recently demonstrated that a bolus of a Class 1B antiarrhythmic drug was able to trigger a ventricular fibrillation due to transient blocks induction. The aim of the present work was to systematically study, by use of the van Capelle and Durrer (VCD) model which allows to simulate ventricular activation wave propagation, the link between arrhythmogenic effects and the ability of transient blocks to possibly degenerate in severe arrhythmias. A fragment of the ventricular wall is represented by an array of 16384elements electrically coupled. Effects of induction of one or several transient blocks, as the effects of their size and duration on possible induction of reentries have been studied. Results obtained show that various combinations between these different parameters may trigger reentries, ventricular tachycardia and/or more complex patterns assimilable to ventricular fibrillation. These results clearly evidence the fact that possible induction of transient blocks may directly be related to risk factor associated to arrhythmogenic effects of antiarrhythmic drugs|
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
Peter Gärdenfors (1990). Induction, Conceptual Spaces and AI. Philosophy of Science 57 (1):78-95.
Alain L. Bardou, Pierre M. Auger, Soumeya Achour, Philippe Dumee, Pierre J. Birkui & Marie-Claude Govaere (1995). Effect of Myocardial Infarction and Ischemia on Induction of Cardiac Reentries and Ventricular Fibrillation. Acta Biotheoretica 43 (4).
A. L. Bardou, R. G. Seigneuric, J.-L. Chassé & P. M. Auger (1999). Incidence of Dispersion of Refractoriness and Cellular Coupling Resistance on Cardiac Reentries and Ventricular Fibrillation. Acta Biotheoretica 47 (3-4).
P. Auger, R. Cardinal, A. Bril, L. Rochette & A. Bardou (1992). Interpretation of Epicardial Mapping by Means of Computer Simulations: Applications to Calcium, Lidocaine and to BRL 34915. Acta Biotheoretica 40 (2-3).
Stephen T. Higgins & Stacey C. Sigmon (2000). Implications of Behavioral Momentum for Understanding the Behavioral Pharmacology of Abused Drugs. Behavioral and Brain Sciences 23 (1):101-101.
Ryota Kanai, Farshad Moradi, Shinsuke Shimojo & Frans A. J. Verstraten (2005). Perceptual Alternation Induced by Visual Transients. Perception 34 (7):803-822.
Bengt Brülde (2007). Can Succesful Mood Enhancement Make Us Less Happy? Philosophica 79:39-56.
A. I. Hernández, G. Carrault, F. Mora & A. Bardou (2000). Overview of Carmem: A New Dynamic Quantitative Cardiac Model for ECG Monitoring and its Adaptation to Observed Signals. Acta Biotheoretica 48 (3-4).
Sorry, there are not enough data points to plot this chart.
Added to index2009-01-28
Total downloads1 ( #291,386 of 722,836 )
Recent downloads (6 months)0
How can I increase my downloads?