From molecules to behavior and the clinic: Integration in chronobiology

Abstract
Chronobiology, especially the study of circadian rhythms, provides a model scientific field in which philosophers can study how investigators from a variety of disciplines working at different levels of organization are each contributing to a multi-level account of the responsible mechanism. I focus on how the framework of mechanistic explanation integrates research designed to decompose the mechanism with efforts directed at recomposition that relies especially on computation models. I also examine how recently the integration has extended beyond basic research to the processes through which the disruption of circadian rhythms contributes to disease, including various forms of cancer. Understanding these linkages has been facilitated by discoveries about how circadian mechanisms interact with mechanisms involved in other physiological processes, including the cell cycle and the immune system
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DOI 10.1016/j.shpsc.2012.10.001
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References found in this work BETA
William Bechtel (2005). Explanation: A Mechanist Alternative. Studies in History and Philosophy of Biol and Biomed Sci 36 (2):421--441.
Ingo Brigandt & Alan Love, Reductionism in Biology. The Stanford Encyclopedia of Philosophy.

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Citations of this work BETA
Ingo Brigandt (2013). Systems Biology and the Integration of Mechanistic Explanation and Mathematical Explanation. Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):477-492.
Sabina Leonelli (2013). Integrating Data to Acquire New Knowledge: Three Modes of Integration in Plant Science. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):503-514.
Anya Plutynski (2013). Cancer and the Goals of Integration. Studies in History and Philosophy of Science Part C (4):466-476.
Ingo Brigandt (2013). Integration in Biology: Philosophical Perspectives on the Dynamics of Interdisciplinarity. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):461-465.

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