David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
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Journal of the History of Biology 40 (1):1 - 33 (2007)
Developing models of biological mechanisms, such as those involved in respiration in cells, often requires collaborative effort drawing upon techniques developed and information generated in different disciplines. Biochemists in the early decades of the 20th century uncovered all but the most elusive chemical operations involved in cellular respiration, but were unable to align the reaction pathways with particular structures in the cell. During the period 1940-1965 cell biology was emerging as a new discipline and made distinctive contributions to understanding the role of the mitochondrion and its component parts in cellular respiration. In particular, by developing techniques for localizing enzymes or enzyme systems in specific cellular components, cell biologists provided crucial information about the organized structures in which the biochemical reactions occurred. Although the idea that biochemical operations are intimately related to and depend on cell structures was at odds with the then-dominant emphasis on systems of soluble enzymes in biochemistry, a reconceptualization of energetic processes in the 1960s and 1970s made it clear why cell structure was critical to the biochemical account. This paper examines how numerous excursions between biochemistry and cell biology contributed a new understanding of the mechanism of cellular respiration
|Keywords||biochemistry cell biology cell fractionation cellular respiration decomposition discipline electron microscopy interdisciplinary interfield theories localization mechanistic explanation metabolism mitochondria|
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Citations of this work BETA
John N. Prebble (2010). The Discovery of Oxidative Phosphorylation: A Conceptual Off-Shoot From the Study of Glycolysis. Studies in History and Philosophy of Science Part C 41 (3):253-262.
Dimitri Ginev (2012). Two Accounts of the Hermeneutic Fore-Structure of Scientific Research. International Studies in the Philosophy of Science 26 (4):423-445.
John N. Prebble (2013). Contrasting Approaches to a Biological Problem: Paul Boyer, Peter Mitchell and the Mechanism of the ATP Synthase, 1961–1985. [REVIEW] Journal of the History of Biology 46 (4):699-737.
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