As well as physiological states, pathological states and therapeutical problems may be a gushing spring for biological theory - and conversely
Acta Biotheoretica 47 (3-4) (1999)
|Abstract||New class of therapies, including bipolar therapies (BPT) and paradoxical unipolar therapies (PUT) were firstly proposed in relation to a clinical insight and to some results of biological investigations, then they gave rise to mathematical modeling which brought a justification of these therapies, at least from a theoretical point of view. After recalling the mathematical model for the regulation of agonistic antagonistic couples, and reporting the fundamental types of control simulation by means of it, we point out the validity of therapeutical applications inferred from this model. These therapy modalities, including BPT and PUT, now concern the following diseases: astrocytomas, epilepsia and trials on multiple sclerosis. Even if such attempts are in their early stage, noticeably for the last case where biological changes have mainly been studied, it seems that a large span of treatments is open to BPT and PUT. Improvement of these techniques in the future depends, in our opinion, on a parallel working on the dynamics of the mathematical model and the dynamics, perceived by clinical insight and confirmed by biological investigations, of the body reactions to such strategies. Justification of BPT and PUT was given, by resorting to the notion of pathological homeostasis which, too often, intervenes in order to nullify the effects of unilateral (not paradoxical) therapies. This research has elicited some therapies which use two agents with antagonistic effects or only an agent with effects similar to the agent already in excess in the body - in both cases at nearly physiological doses.|
|Keywords||No keywords specified (fix it)|
|Through your library||Configure|
Similar books and articles
Axel Cleeremans & John Haynes (1999). Correlating Consciousness: A Vew From Empirical Science. Revue Internationale de Philosophie 3 (209):387-420.
Cynthia B. Cohen Peter J. Cohen (2010). International Stem Cell Tourism and the Need for Effective Regulation: Part II: Developing Sound Oversight Measures and Effective Patient Support. Kennedy Institute of Ethics Journal 20 (3):207-230.
Benoni B. Edin (2008). Assigning Biological Functions: Making Sense of Causal Chains. Synthese 161 (2):203 - 218.
C. Vauge, B. Carbonne, E. Papiernik & F. Ferré (2000). A Mathematical Model of Uterine Dynamics and its Application to Human Parturition. Acta Biotheoretica 48 (2).
Mauro Nervi (2010). Mechanisms, Malfunctions and Explanation in Medicine. Biology and Philosophy 25 (2):215-228.
Daniel J. Benor (2002). Energy Medicine for the Internist. [Journal (on-Line/Unpaginated)].
E. Bernard-Weil (2000). Does Help in Decision-Making in Biology Help in Decision-Making in Human Sciences and Conversely? Acta Biotheoretica 48 (3-4).
B. Delord (1999). Attractors and Pathological Aspects in Excitable Cells. Acta Biotheoretica 47 (3-4).
Sorry, there are not enough data points to plot this chart.
Added to index2009-01-28
Recent downloads (6 months)0
How can I increase my downloads?