David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Poiesis and Praxis 3 (s 1-2):73-82 (2004)
Genetic variability and diversity are the result of a mutation-selection balance that acts permanently within and between species. The presence of deleterious mutations is a necessary consequence of this process and thus “the price paid by a species for its capacity for further evolution” (Haldane 1937, Am Nat 71:337–349). Recent estimations of mutation rate in the human lineage has revived the debate as to whether the high number of deleterious mutations poses a severe problem for the future of mankind. Theoretical considerations allow a scenario in which the survival of the human race is maintained by truncation selection of deleterious mutations that removes as many mutations as appear anew in every generation. In this case our genetic burden is carried by those individuals that suffer a genetic death resulting from random distribution of deleterious alleles. Nevertheless, one has to ask whether the mutation rate may set absolute limits on the complexity of a species
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Colin Farrelly (2007). Genetic Justice Must Track Genetic Complexity. Cambridge Quarterly of Healthcare Ethics 17 (01):45-53.
I. Walker (1996). Prediction of Evolution? Somatic Plasticity as a Basic, Physiological Condition for the Viability of Genetic Mutations. Acta Biotheoretica 44 (2).
Hampton L. Carson (1993). Human Genetic Diversity, a Critical Resource for Man's Future. Biology and Philosophy 8 (1):33-45.
Armando Aranda-Anzaldo (2001). Cancer Development and Progression: A Non-Adaptive Process Driven by Genetic Drift. Acta Biotheoretica 49 (2).
Russell Powell (2010). The Evolutionary Biological Implications of Human Genetic Engineering. Journal of Medicine and Philosophy 37 (1):22.
Masatoshi Nei (2007). The New Mutation Theory of Phenotypic Evolution. Proc Natl Acad Sci U S A 104 (30):12335-12242.
J. T. Manning & D. J. Thompson (1984). Muller's Ratchet and the Accumulation of Favourable Mutations. Acta Biotheoretica 33 (4).
Michael B.�Lker (2004). Bear Ye One Another?S Genetic Burdens: The Price of Diversity and Complexity. Poiesis and Praxis 3 (1-2):73-82.
Added to index2009-01-28
Total downloads4 ( #272,677 of 1,140,334 )
Recent downloads (6 months)1 ( #140,127 of 1,140,334 )
How can I increase my downloads?