Graduate studies at Western
Cell Stem Cell 8 (5):468-475 (2011)
|Abstract||Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs). This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI patients for a safety trial, subacute incomplete SCI patients for an efficacy trial, and perhaps primary progressive multiple sclerosis (MS) patients for a combined safety and efficacy trial.|
|Keywords||First-in-human Clinical trial Stem Cells Human embryonic stem cells|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
Andrew Fenton & Frederic Gilbert (2011). On the Use of Animals in Emergent Embryonic Stem Cell Research for Spinal Cord Injuries. Journal of Animal Ethics 1 (1):37-45.
Mark T. Brown (2009). Moral Complicity in Induced Pluripotent Stem Cell Research. Kennedy Institute of Ethics Journal 19 (1):pp. 1-22.
David van Gend (2011). Geron and the Demise of Embryonic Stem Cell Science. Bioethics Research Notes 23 (4):51.
Nikolaus Knoepffler (2004). Stem Cell Research: An Ethical Evaluation of Policy Options. Kennedy Institute of Ethics Journal 14 (1):55-74.
Lawrence Burns (2009). “You Are Our Only Hope”: Trading Metaphorical “Magic Bullets” for Stem Cell “Superheroes”. Theoretical Medicine and Bioethics 30 (6):427-442.
John D. Loike Moshe Tendler (2008). Reconstituting a Human Brain in Animals: A Jewish Perspective on Human Sanctity. Kennedy Institute of Ethics Journal 18 (4):pp. 347-367.
Joseph J. Fins & Madeleine Schachter (2002). Patently Controversial: Markets, Morals, and the President's Proposal for Embryonic Stem Cell Research. Kennedy Institute of Ethics Journal 12 (3):265-278.
Philip J. Nickel (2008). Ethical Issues in Human Embryonic Stem Cell Research. In Kristen Renwick Monroe, Ronald B. Miller & Jerome Tobis (eds.), Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical & Political Issues. University of California Press.
Bernard Dickens, International Society for Stem Cell Research (ISSCR) Guidelines for the Conduct of Human Embryonic Stem Cell Research (December 2006).
Rebecca Dresser (2010). Stem Cell Research as Innovation: Expanding the Ethical and Policy Conversation. Journal of Law, Medicine and Ethics 38 (2):332-341.
Michael R. Prieur, Joan Atkinson, Laurie Hardingham, David Hill, Gillian Kernaghan, Debra Miller, Sandy Morton, Mary Rowell, John F. Vallely & Suzanne Wilson (2006). Stem Cell Research in a Catholic Institution: Yes or No? Kennedy Institute of Ethics Journal 16 (1):73-98.
Shelley Tremain (2006). Stemming the Tide of Normalisation: An Expanded Feminist Analysis of the Ethics and Social Impact of Embryonic Stem Cell Research. [REVIEW] Journal of Bioethical Inquiry 3 (1-2):33-42.
Norman Ford (2007). Stem Cells, Altered Nuclear Transfer & Ethics. Chisholm Health Ethics Bulletin 12 (3):9.
O. Carter Snead (2012). The Law and Politics of Embryo Research in America. Human Reproduction and Genetic Ethics 17 (1):40-52.
LeRoy Walters (2004). Human Embryonic Stem Cell Research: An Intercultural Perspective. Kennedy Institute of Ethics Journal 14 (1):3-38.
Added to index2011-07-12
Total downloads7 ( #142,473 of 740,168 )
Recent downloads (6 months)1 ( #61,680 of 740,168 )
How can I increase my downloads?