David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 40 (2-3):205-220 (1992)
The differentiation of T Lymphocytes within the thymus is an important biological phenomenon during wich these cell acquire their functions to further control the immune system. Numerous experiments under various conditions have been devised to understand the different mechanisms involved in this complex process. Nevertheless, interpretation of these experiments lead to still contradictory debatable hypotheses. Modelisation of this process through classical simulation methods cannot be envisaged because they are not adapted to modifications of the model structure, which is the point of interest. For these reasons, we proposed a new approach of automatic search for model. The program consists of four independent connected modules : The generator produces model, based on the rationale of formal grammars. Protocol and experimental data are stored in a set of experiments. The simulator using a protocol and a model provides simulated results. Finally, the supervisor by comparing simulated results and experimental data, adapts the model parameters to increase their fit and either chooses a new experiment to explore, or modifies the model structure. Change of the model structure is performed among still unexplored models according to their promise level, which is iteratively evaluated relatively to previously explored models through a proposed model distance. The generator is written in Prolog and the other modules in C++. The architecture of the program allows us to modify or complete a module without changing anything in the other modules. As a consequence, the proposed modeling approach conceived to study T lymphocyte differentiation within the thymus remains independent of this biological phenomenon and can be applied to other biological problems.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Daniel L. Young & Chi-Sang Poon (2001). Soul Searching and Heart Throbbing for Biological Modeling. Behavioral and Brain Sciences 24 (6):1080-1081.
V. Lemesle & L. Mailleret (2008). A Mechanistic Investigation of the Algae Growth “Droop” Model. Acta Biotheoretica 56 (1):87-102.
Didier Morel, Raphaël Marcelpoil & Gérard Brugal (2001). A Proliferation Control Network Model: The Simulation of Two-Dimensional Epithelial Homeostasis. Acta Biotheoretica 49 (4):219-234.
M. J. Baum & S. A. Tobet (1998). Sexual Differentiation of Callosal Size: Hormonal Mechanisms and the Choice of an Animal Model. Behavioral and Brain Sciences 21 (3):328-328.
Mark L. Taper, David F. Staples & Bradley B. Shepard (2008). Model Structure Adequacy Analysis: Selecting Models on the Basis of Their Ability to Answer Scientific Questions. Synthese 163 (3):357 - 370.
L. Taper Mark, F. Staples David & B. Shepard Bradley (2008). Model Structure Adequacy Analysis: Selecting Models on the Basis of Their Ability to Answer Scientific Questions. Synthese 163 (3).
Carole J. Clem & Jean Paul Rigaut (1995). Computer Simulation Modelling and Visualization of 3d Architecture of Biological Tissues. Acta Biotheoretica 43 (4):425-442.
Pierre F. Baconnier, Catherine Marey & Ahmed Ménaouar (1997). Simulation of Pulmonay Damages Induced by Inhaled CL2 on the Bronchial Tree. Acta Biotheoretica 45 (3-4):237-250.
Added to index2009-01-28
Total downloads7 ( #440,909 of 1,911,732 )
Recent downloads (6 months)3 ( #254,551 of 1,911,732 )
How can I increase my downloads?