David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Behavioral and Brain Sciences 20 (3):404-419 (1997)
This target article examines the clinical and experimental evidence for a role of peripheral and central hyperexcitability in persistent pain in four key areas: cutaneous hyperalgesia, referred pain, neuropathic pain, and postoperative pain. Each suggests that persistent pain depends not only on central sensitization, but also on inputs from damaged peripheral tissue. It is instructive to think of central sensitization as comprised of both an initial central sensitization and an ongoing central sensitization driven by inputs from peripheral sources. Each of these factors, initial sensitization, ongoing central sensitization, and inputs from peripheral sources, contributes to the net activity in dorsal horn neurons and thus influences the expression of persistent pain or hyperalgesia. Since each factor, peripheral inputs and central sensitization (initial or ongoing), can contribute to both the initiation and maintenance of persistent pain, therapies should target both peripheral and central sources of pathology
|Keywords||hyperalgesia neurogenic inflammation neuropathic pain nociception phantom limb pain plasticity postoperative pain pre-emptive analgesia referred pain sensitization|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Maja Pantic & Leon J. M. Rothkrantz (2002). Machine Understanding of Facial Expression of Pain. Behavioral and Brain Sciences 25 (4):469-470.
Marshall Devor (1997). Central Versus Peripheral Substrates of Persistent Pain: Which Contributes More? Behavioral and Brain Sciences 20 (3):446-446.
John Nessa (1996). About Signs and Symptoms: Can Semiotics Expand the View of Clinical Medicine? Theoretical Medicine and Bioethics 17 (4).
D. Resnik (2000). Pain as a Folk Psychological Concept: A Clinical Perspective. [REVIEW] Brain and Mind 1 (2):193-207.
Adam J. Kolber (2007). Pain Detection and the Privacy of Subjective Experience. American Journal of Law & Medicine 33 (2&3):433-456.
Ilchi Lee (2009). Meridian Exercise for Self-Healing: Classified by Common Symptoms: Back Pain, Headaches, Colds, Flu, Joint and Muscle Pain, Insomnia. Best Life Media.
C. R. Chapman & Yutaka Nakamura (1999). A Passion of the Soul: An Introduction to Pain for Consciousness Researchers. Consciousness and Cognition 8 (4):391-422.
Clarissa De Rosalmeida Dantas & Claudio E. M. Banzato (2010). Raising Awareness of Values in the Recognition of Negative Symptoms of Schizophrenia. Dialogues in Philosophy, Mental and Neuro Sciences 3 (2):35-41.
Terence J. Coderre & Joel Katz (1997). What Exactly is Central to the Role of Central Neuroplasticity in Persistent Pain? Behavioral and Brain Sciences 20 (3):483-486.
Added to index2009-01-28
Total downloads18 ( #133,942 of 1,696,626 )
Recent downloads (6 months)1 ( #346,146 of 1,696,626 )
How can I increase my downloads?