David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 44 (3-4) (1996)
The aim of this paper is to compare various methods for the quantification of metabolic pathways dynamics. A Yates-Pardee metabolic pathway with enzyme organization, i.e. with spatial localization of the enzymes in a specific cellular compartment, was studied using: (i) the classical Henri-Michaelis-Menten (HMM) equations, (ii) linearization of the HMM equations in the vicinity of a steady state (linearized formalism), and (iii) Biochemical Systems Theory formalism (BST formalism). It is shown that transient solutions computed via either the linearized formalism or the BST formalism can greatly differ from transient solutions computed with the HMM equations. However, in the studied example, results remain qualitatively the same for the three formalisms. This suggests that the study of the topology of the system may give useful insights into the metabolic pathways dynamics.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
A. M. Perault-Staub, P. Tracqui & J. F. Staub (1992). Modelling of in Vivo Calcium Metabolism. I. Optimal Cooperation Between Constant and Rhythmic Behaviours. Acta Biotheoretica 40 (2-3).
B. Raïs, C. Chassagnole & J. -P. Mazat (1995). Control of Threonine Pathway in E. Coli. Application to Biotechnologies. Acta Biotheoretica 43 (4).
Mike Ainsworth (1993). Abpl. Acta Biotheoretica 41 (1-2).
Kepa Ruiz-Mirazo, Jon Umerez & Alvaro Moreno (2008). Enabling Conditions for 'Open-Ended Evolution'. Biology and Philosophy 23 (1):67-85.
Jacques Droulez (2010). The Probabilistic Cell: Implementation of a Probabilistic Inference by the Biochemical Mechanisms of Phototransduction. Acta Biotheoretica 58 (2):103-120.
F. J. Bruggeman, H. V. Westerhoff & F. C. Boogerd (2002). Biocomplexity: A Pluralist Research Strategy is Necessary for a Mechanistic Explanation of the "Live" State. Philosophical Psychology 15 (4):411 – 440.
Hans V. Westerhoff & Daniel Kahn (1993). Control Involving Metabolism and Gene Expression. Acta Biotheoretica 41 (1-2).
Dominique de Vienne, Bruno Bost, Julie Fiévet & Christine Dillmann (2001). Optimisation of Enzyme Concentrations for Unbranched Reaction Chains: The Concept of Combined Response Coefficient. Acta Biotheoretica 49 (4).
Pedro Mendes & Douglas B. Kell (1993). On the Role of Enzyme Kinetic Parameters in Determining the Effectiveness with Which Channelling Can Decrease the Size of a Metabolite Pool. Acta Biotheoretica 41 (1-2).
Sorry, there are not enough data points to plot this chart.
Added to index2009-01-28
Total downloads1 ( #390,893 of 1,096,179 )
Recent downloads (6 months)0
How can I increase my downloads?