In search of the best explanation about the nature of the Gene: Avery on pneumococcal transformation
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
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Studies in History and Philosophy of Science Part C 39 (1):65-79 (2008)
In this paper I present a model of rational belief change, and I show how to use it to obtain a better insight into the debate about the nature of pneumococcal transformation, genes and DNA that took place in the forties, as a result of Oswald T. Avery’s work. The model offers a particular elaboration of the concept of inference to the best explanation, along decision theoretic lines. Within this framework, I distinguish different senses in which Avery’s team can be said to have proceeded with caution, thus throwing some light upon a persistent source of disagreement among researchers in the history of genetics. In addition, I explain why we are entitled to say that rival parties such as physicist Maclyn McCarty and biochemist Alfred Mirsky were epistemically rational, in spite of the fact that they reached different conclusions on the basis of the same evidence
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References found in this work BETA
Philip Kitcher (1984). 1953 and All That. A Tale of Two Sciences. Philosophical Review 93 (3):335-373.
Raimo Tuomela (2000). Belief Versus Acceptance. Philosophical Explorations 3 (2):122 – 137.
Timothy Day & Harold Kincaid (1994). Putting Inference to the Best Explanation in its Place. Synthese 98 (2):271-295.
S. Okasha (2000). Van Fraassen's Critique of Inference to the Best Explanation. Studies in History and Philosophy of Science Part A 31 (4):691-710.
Philip Kitcher (1982). Genes. British Journal for the Philosophy of Science 33 (4):337-359.
Citations of this work BETA
Pierre-Olivier Méthot (forthcoming). Bacterial Transformation and the Origins of Epidemics in the Interwar Period: The Epidemiological Significance of Fred Griffith’s “Transforming Experiment”. Journal of the History of Biology.
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