Reasoning Strategies in Molecular Biology: Abstractions, Scans and Anomalies

Molecular biologists use different kinds of reasoning strategies for different tasks, such as hypothesis formation, experimental design, and anomaly resolution. More specifically, the reasoning strategies discussed in this paper may be characterized as (1) abstraction-instantiation, in which an abstract skeletal model is instantiated to produce an experimental system; (2) the systematic scan, in which alternative hypotheses are systematically generated; and (3) modular anomaly resolution, in which components of a model are stated explicitly and methodically changed to generate alternative changes to resolve an anomaly. This work grew out of close observation over a period of six months of an actively functioning molecular genetics laboratory.
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Lindley Darden & Carl Craver (2002). Strategies in the Interfield Discovery of the Mechanism of Protein Synthesis. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 33 (1):1-28.

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Lindley Darden (1992). Strategies for Anomaly Resolution. In R. Giere & H. Feigl (eds.), Cognitive Models of Science. University of Minnesota Press
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