Multi-formalism modelling and simulation: Application to cardiac modelling
Acta Biotheoretica 52 (4) (2004)
| Abstract | Cardiovascular modelling has been a major research subject for the last decade. Different cardiac models have been developed at a cellular level as well as at the whole organ level. Most of these models are defined by a comprehensive cellular modelling using continuous formalisms or by a tissue-level modelling often based on discrete formalisms. Nevertheless, both views still suffer from difficulties that reduce their clinical applications: the first approach requires heavy computational resources while the second one is not able to reproduce certain pathologies.This paper presents an original methodology trying to gather advantages from both approaches, by means of a hybrid model mixing discrete and continuous formalisms. This method has been applied to define a hybrid model of cardiac action potential propagation on a 2D grid of endocardial cells, combining cellular automata and a set of cells defined by the Beeler-Reuter model. For simulations under physiological and ischemic conditions, results show that the action potential propagation as well as electrogram reconstructions are consistent with clinical diagnosis. Finally, the advantage of the proposed approach is discussed within the frame of cardiac modelling and simulation. | |||||||||
| Keywords | No keywords specified (fix it) | |||||||||
| Categories | ||||||||||
| Options |
|
|||||||||
Download options| PhilPapers Archive |
Upload a copy of this paper Check publisher's policy on self-archival Papers currently archived: 5,664 |
| External links |
 |
| Through your library | Configure |
Similar books and articlesEtienne Roux, Penelope J. Noble, Jean-Marc Hyvelin & Denis Noble (2001). Modelling of Ca2+-Activated Chloride Current in Tracheal Smooth Muscle Cells. Acta Biotheoretica 49 (4).
Mike Page (2000). Connectionist Modelling in Psychology: A Localist Manifesto. Behavioral and Brain Sciences 23 (4):443-467.
Stephen Gorard (2003). What Is Multi-Level Modelling For? British Journal of Educational Studies 51 (1):46 - 63.
Jeffrey C. Schank (2001). Dimensions of Modelling: Generality and Integrativeness. Behavioral and Brain Sciences 24 (6):1075-1076.
Bruce Edmonds (2000). Complexity and Scientific Modelling. Foundations of Science 5 (3):379-390.
Jarmo J. Ahonen (1994). On Qualitative Modelling. AI and Society 8 (1):17-28.
Analytics
Monthly downloads
Sorry, there are not enough data points to plot this chart.
|
Added to index2009-01-28Total downloads1 ( #274,556 of 549,005 )Recent downloads (6 months)0How can I increase my downloads? |
My notes
Discussion
