David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Science and Engineering Ethics 10 (1):143-150 (2004)
A great variety of medical conditions are subject to the placebo effect. Although there is mounting evidence to suggest that the placebo effect is related to the expectation of clinical benefit, little is still known about the biochemical bases underlying placebo responses. Positron emission tomography studies have recently shown that the placebo effect in Parkinson’s disease, pain, and depression is related to the activation of the limbic circuitry. The observation that placebo administration induces the release of dopamine in the ventral striatum of patients with Parkinson’s disease suggests a link between the placebo effect and reward mechanisms. In addition to Parkinson’s disease, the placebo-reward model may also apply to other disorders. However, the relative contribution of the different neurotransmitters and neuropeptides that are known to be involved in modulating the activity of the limbic system may be disease-specific. Thus, while the placebo-induced clinical benefit observed in Parkinson’s disease would mostly reflect the release of dopamine in the dorsal striatum, the activation of opioid and serotonin pathways could be particularly implicated in mediating placebo responses encountered in pain and depression, respectively.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Olov Lindahl & Lars Lindwall (1982). Is All Therapy Just a Placebo Effect? Theoretical Medicine and Bioethics 3 (2):255-259.
Franklin G. Miller & Luana Colloca (2010). Semiotics and the Placebo Effect. Perspectives in Biology and Medicine 53 (4):509-516.
Matthew Haug (2011). Explaining the Placebo Effect: Aliefs, Beliefs, and Conditioning. Philosophical Psychology 24 (5):679 - 698.
Connie Peck & Grahame Coleman (1991). Implications of Placebo Theory for Clinical Research and Practice in Pain Management. Theoretical Medicine and Bioethics 12 (3).
Mary Faith Marshall (2004). The Placebo Effect in Popular Culture. Science and Engineering Ethics 10 (1):37-42.
Andrew Turner (2012). 'Placebos' and the Logic of Placebo Comparison. Biology and Philosophy 27 (3):419-432.
F. G. Miller & H. Brody (2011). Understanding and Harnessing Placebo Effects: Clearing Away the Underbrush. Journal of Medicine and Philosophy 36 (1):69-78.
Thomas R. Weihrauch (2004). Placebo Treatment is Effective Differently in Different Diseases — but is It Also Harmless? A Brief Synopsis. Science and Engineering Ethics 10 (1):151-155.
Robert J. Connelly (1991). Nursing Responsibility for the Placebo Effect. Journal of Medicine and Philosophy 16 (3):325-341.
Nikola Biller-Andorno (2004). The Use of the Placebo Effect in Clinical Medicine — Ethical Blunder or Ethical Imperative? Science and Engineering Ethics 10 (1):43-50.
Added to index2009-01-28
Total downloads18 ( #89,673 of 1,096,899 )
Recent downloads (6 months)1 ( #273,368 of 1,096,899 )
How can I increase my downloads?