Randomised placebo-controlled trials and HIV-infected pregnant women in developing countries. Ethical imperialism or unethical exploitation
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
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Bioethics 15 (4):289–311 (2001)
In this paper, I provide a brief summary of the context, outline the arguments for and against the controversial use of placebo controls, and focus on particular areas that I believe merit further discussion or clarification. On balance, I argue that the researchers failed in their duties to protect the best interests of their research subjects, and to promote distributive justice. I discuss the difficulties of obtaining valid consent in this research context, and argue that it is unethical to inform women of their 'HIV' status without at least offering them prophylactic treatment for their unborn children. (edited).
|Keywords||info:mesh/Infectious Disease Transmission, Vertical info:mesh/Informed Consent info:mesh/Social Justice info:mesh/Ethical Analysis info:mesh/Pregnancy info:mesh/Internationality info:mesh/Research Design info:mesh/Humans info:mesh/Developing Countries info:mesh/Placebos info:mesh/Randomized Controlled Trials as Topic info:mesh/Pregnant Women info:mesh/HIV Infections info:mesh/Female info:mesh/Helsinki Declaration info:mesh/Zidovudine info:mesh/Ethics, Research info:mesh/Human Experimentation Humans HIV Infections Zidovudine Placebos Human Experimentation Pregnancy Research Design Internationality Developing Countries Informed Consent Social Justice Ethical Analysis Helsinki Declaration Ethics, Research Pregnant Women Female Randomized Controlled Trials as Topic Infectious Disease Transmission, Vertical|
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Paul Farmer & Nicole Gastineau Campos (2004). New Malaise: Bioethics and Human Rights in the Global Era. Journal of Law, Medicine & Ethics 32 (2):243-251.
Cynthia Eyakuze, Debra A. Jones, Ann M. Starrs & Naomi Sorkin (2008). From Pmtct to a More Comprehensive Aids Response for Women: A Much-Needed Shift. Developing World Bioethics 8 (1):33–42.
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