Graduate studies at Western
Perspectives on Science 12 (3):320-338 (2004)
|Abstract||: Recent molecular biology has seen the development of genomics as a successor to traditional genetics. This paper offers an overview of the structure, epistemology, and (very briefly) history of contemporary genomics. A particular focus is on the question to what extent the genome contains, or is composed of, anything that corresponds to traditional conceptions of genes. It is concluded that the only interpretation of genes that has much contemporary scientific relevance is what is described as the "developmental defect" gene concept. However, developmental defect genes typically only correspond to general areas of the genome and not to precise chemical structures (nucleotide sequences). The parts of the genome to be identified for an account of the processes of normal development are highly diverse, little correlated with traditional genes, and act in ways that are highly dependent on the cellular and higher level environment. Despite its historical development out of genetics, genomics represents a radically different kind of scientific project|
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
Herman T. Tavani (2004). Genomic Research and Data-Mining Technology: Implications for Personal Privacy and Informed Consent. Ethics and Information Technology 6 (1):15-28.
Brant Pridmore (2008). Review of Genes in Development: Re-Reading the Molecular Paradigm. [REVIEW] Biology and Philosophy 23 (4):579-586.
Alexander Powell, Maureen A. O'Malley, Staffan Mueller-Wille, Jane Calvert & John Dupré (2007). Disciplinary Baptisms: A Comparison of the Naming Stories of Genetics, Molecular Biology, Genomics and Systems Biology. History and Philosophy of the Life Sciences 29 (1):5-32.
C. Kenneth Waters (1994). Genes Made Molecular. Philosophy of Science 61 (2):163-185.
Peter J. Beurton, Raphael Falk & Hans-Jörg Rheinberger (eds.) (2000). The Concept of the Gene in Development and Evolution: Historical and Epistemological Perspectives. Cambridge University Press.
Lenny Moss (2006). Redundancy, Plasticity, and Detachment: The Implications of Comparative Genomics for Evolutionary Thinking. Philosophy of Science 73 (5):930-946.
Ehud Lamm (2010). Genes Versus Genomes: The Role of Genome Organization in Evolution. Dissertation, Tel Aviv University
John Dupre (2004). Understanding Contemporary Genomics. Perspectives on Science 12 (3):320-338.
Holmes Rolston (2006). What is a Gene? From Molecules to Metaphysics. Theoretical Medicine and Bioethics 27 (6):471-497.
Catherine Kendig, Reconstructing the Concept of Homology for Genomics. Pittsburgh/London Colloquium on Philosophy of Biology and Neuroscience, University of London. Online at PhilSci Archive.
Added to index2009-01-28
Total downloads22 ( #62,772 of 739,369 )
Recent downloads (6 months)4 ( #20,616 of 739,369 )
How can I increase my downloads?