David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
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Perspectives on Science 12 (3):320-338 (2004)
Recent molecular biology has seen the development of genomics as a successor to traditional genetics. This paper offers an overview of the structure, epistemology, and history of contemporary genomics. A particular focus is on the question to what extent the genome contains, or is composed of, anything that corresponds to traditional conceptions of genes. It is concluded that the only interpretation of genes that has much contemporary scientific relevance is what is described as the "developmental defect" gene concept. However, developmental defect genes typically only correspond to general areas of the genome and not to precise chemical structures . The parts of the genome to be identified for an account of the processes of normal development are highly diverse, little correlated with traditional genes, and act in ways that are highly dependent on the cellular and higher level environment. Despite its historical development out of genetics, genomics represents a radically different kind of scientific project
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Maureen O'Malley, Jane Calvert & John Dupré (2007). The Study of Socioethical Issues in Systems Biology. American Journal of Bioethics 7 (4):67-78.
P. van Haperen, B. Gremmen & J. Jacobs (2012). Reconstruction of the Ethical Debate on Naturalness in Discussions About Plant-Biotechnology. Journal of Agricultural and Environmental Ethics 25 (6):797-812.
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