David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Studies in History and Philosophy of Science Part C 34 (3):455-472 (2003)
The role of the Nobel Laureate Henry Dale (1875-1968) in the history of allergy and the association of anaphylactic conditions with the liberation of histamine is often overlooked. This paper examines his work in this field in the broader context of his researches into endogenous mediators of normal physiological and abnormal pathological functioning. It also assesses the impact of his working environment, especially the unique conditions he enjoyed at the beginning of the twentieth century in the Wellcome Physiological Research Laboratories (WPRL). The WPRL belonged to the pharmaceutical manufacturer Henry Wellcome, and it was the juxtaposition of the routine commercial obligation of testing drugs for Burroughs, Wellcome & Co., with the opportunities of pursuing unfettered physiological research in well-equipped and supported laboratories, that resulted in what Dale referred to as 'happy accidents' when one set of results suggested experimental strategies and designs to another circumstance. In this way an observation of an unusual effect of an extract of ergot of rye led to collaborative chemical and physiological explorations which revealed the presence of histamine, previously known only as a synthetic product. Further work, accidentally facilitated by the fact that the WPRL produced serum anti-toxins commercially and surplus horse serum was used in experiments where other physiologists routinely used saline, hinted that histamine played a role in the symptom complex known as anaphylaxis. This paper explores some of these themes and elaborates their significance.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Jonathan Schaffer (2007). Deterministic Chance? British Journal for the Philosophy of Science 58 (2):113 - 140.
O. Parnes (2003). 'Trouble From Within': Allergy, Autoimmunity, and Pathology in the First Half of the Twentieth Century. Studies in History and Philosophy of Science Part C 34 (3):425-454.
Henry Gans (2011). Reflections on the History and Ethics of the Proper Attribution and Misappropriation of Merit. Perspectives in Biology and Medicine 54 (4):470-478.
Henning Schmidgen (2004). Pictures, Preparations, and Living Processes: The Production of Immediate Visual Perception (Anschauung) in Late-19th-Century Physiology. [REVIEW] Journal of the History of Biology 37 (3):477 - 513.
G. Mitman (2003). Natural History and the Clinic: The Regional Ecology of Allergy in America. Studies in History and Philosophy of Science Part C 34 (3):491-510.
M. Jackson (2003). John Freeman, Hay Fever and the Origins of Clinical Allergy in Britain, 1900-1950. Studies in History and Philosophy of Science Part C 34 (3):473-490.
I. Lowy (2003). On Guinea Pigs, Dogs and Men: Anaphylaxis and the Study of Biological Individuality, 1902-1939. Studies in History and Philosophy of Science Part C 34 (3):399-423.
E. M. Tansey (2003). Henry Dale, Histamine and Anaphylaxis: Reflections on the Role of Chance in the History of Allergy. Studies in History and Philosophy of Science Part C 34 (3):455-472.
Added to index2009-01-28
Total downloads7 ( #213,303 of 1,679,301 )
Recent downloads (6 months)1 ( #183,793 of 1,679,301 )
How can I increase my downloads?