Integrated research into the nanoparticle-protein corona: A new multidisciplinary focus for safe, sustainable and equitable development of nanomedicines
| Abstract | Much contemporary nanotoxicology, nanotherapeutic and nanoregulatory research has been characterised by a focus on investigating how delivery of engineered nanoparticles (ENPs) to cells is dictated primarily by components of the ENP surface. An alternative model, some implications of which are discussed here, begins with fundamental physicochemical research into the interaction of a dynamic nanoparticle-protein corona (NPC) with biological systems. The proposed new model also requires, however, that any such fresh NPC physicochemical research approach should involve integration and targeted collaboration from the earliest stages with nanotoxicology, nanotherapeutics and nanoregulatory expertise. The justification for this integrated approach, we argue, relates not just to efficiency and promotion of innovation, but to an acknowledgement that public-funded basic physicochemical research in particular should now be accepted to incorporate strong higher order public goods elements from its inception, not merely after product development at the technology transfer stage. Issues, in other words, such as university research co-operation, commercialization and intellectual property (IP) protection, safety and cost-effectiveness regulatory assessment, as well as technology transfer should not be viewed as second tier considerations even in a ‘blue sky’ NPC basic research agenda. | |||||||||
| Keywords | No keywords specified (fix it) | |||||||||
| Categories | No categories specified (fix it) | |||||||||
| Options |
|
|||||||||
Download options| PhilPapers Archive |
Upload a copy of this paper Check publisher's policy on self-archival Papers currently archived: 5,705 |
| External links |
  Try with proxy. |
| Through your library | Only published papers are available at libraries |
Similar books and articlesJoseph Agassi (1980). Between Science and Technology. Philosophy of Science 47 (1):82-99.
Andrzej Górski (2006). The Responsible Conduct of Basic and Clinical Research. Science and Engineering Ethics 12 (1):3-4.
Michael Devaney (2004). Government Subsidized Academic Research: Economic and Ethical Conflicts. Journal of Academic Ethics 2 (3).
James S. Leming (1981). Curricular Effectiveness in Moral/Values Education: A Review of Research. [REVIEW] Journal of Moral Education 10 (3):147-164.
Kåre Nielsen, Børge Fredriksen & Anne Myhr (2011). Mapping Uncertainties in the Upstream: The Case of PLGA Nanoparticles in Salmon Vaccines. Nanoethics 5 (1):57-71.
Muel Kaptein & Mark S. Schwartz (2008). The Effectiveness of Business Codes: A Critical Examination of Existing Studies and the Development of an Integrated Research Model. Journal of Business Ethics 77 (2):111 - 127.
Vincent Norcia (2005). Intellectual Property and the Commercialization of Research and Development. Science and Engineering Ethics 11 (2):203-219.
Vincent di Norcia (2005). Intellectual Property and the Commercialization of Research and Development. Science and Engineering Ethics 11 (2).
Analytics
Monthly downloads |
Added to index2009-05-17Total downloads4 ( #178,800 of 549,198 )Recent downloads (6 months)0How can I increase my downloads? |
My notes
Discussion
