An information-processing theory of anesthesia
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
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Neuropsychologia 33:1169-80 (1995)
A theory of anaesthesia is presented. It consists of four hypotheses: (1) The occurrence of states of consciousness causally depends on the formation of transient higher-order, self-referential mental representations. The occurrence of such states is identical with the appearance of conscious phenomena. Loss of consciousness will occur, if and only if the brain's representational activity falls below a critical threshold. (2) Mental representations are instantiated by neural cell assemblies. (3) The formation of assemblies involves the activation of the NMDA receptor channel complex. The activation state of this receptor determines the rate at which assemblies are generated. (4) General anaesthetics have a common operative mechanism: they directly or indirectly affect the function of the NMDA system.
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Francesco Marchi & Albert Newen (2016). The Cognitive Foundations of Visual Consciousness: Why Should We Favour a Processing Approach? Phenomenology and the Cognitive Sciences 15 (2):247-264.
Alexander A. Fingelkurts & Andrew A. Fingelkurts (2014). Do We Need a Theory-Based Assessment of Consciousness in the Field of Disorders of Consciousness? Frontiers in Human Neuroscience 8:402.
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