A general formalism for tissue morphogenesis based on cellular dynamics and control system interactions
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica (forthcoming)
Morphogenesis is a key process in developmental biology. An important issue is the understanding of the generation of shape and cellular organisation in tissues. Despite of their great diversity, morphogenetic processes share common features. This work is an attempt to describe this diversity using the same formalism based on a cellular description. Tissue is seen as a multi-cellular system whose behaviour is the result of all constitutive cells dynamics. Morphogenesis is then considered as a spatiotemporal organization of cells activities. We show how this formalism relies on Reaction–Diffusion/Positional Information approach and how it permits to generalize its modelling possibilities. Three quite different applications for concrete morphogenetic processes are presented. The first one is a model for epithelial invagination, the second is a model of cellular differentiation by local cell–cell signalling. The last example is the secondary radial growth of conifer trees. From the mathematical point of view, different modelling tools are used according to the specificity of each process.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Nicolas Rivier, Gudrun Schliecker & Benoît Dubertret (1995). The Stationary State of Epithelia. Acta Biotheoretica 43 (4).
John Collier (2004). Self-organization, Individuation and Identity. Revue Internationale de Philosophie 2:151-172.
Philippe Tracqui & Jacques Ohayon (2004). Transmission of Mechanical Stresses Within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model. Acta Biotheoretica 52 (4).
Robert Costalat (1996). Enzyme Organization and Stability of Metabolic Pathways: A Comparison of Various Approaches. Acta Biotheoretica 44 (3-4).
Michel Ferre & Herve Guyader (1984). The Geometry of Leaf Morphogenesis: A Theoretical Proposition. Acta Biotheoretica 33 (2).
Rosine Chandebois & Jacob Faber (1987). From DNA Transcription to Visible Structure: What the Development of Multicellular Animals Teaches Us. Acta Biotheoretica 36 (2).
Wolfgang Merzenich (1980). Cellular Spaces. Theoretical Medicine and Bioethics 1 (1):51-65.
A. Defontaine, A. Hernández & G. Carrault (2004). Multi-Formalism Modelling and Simulation: Application to Cardiac Modelling. Acta Biotheoretica 52 (4).
Philippe Tracqui (1995). From Passive Diffusion to Active Cellular Migration in Mathematical Models of Tumour Invasion. Acta Biotheoretica 43 (4).
Added to index2009-01-28
Total downloads5 ( #227,243 of 1,101,579 )
Recent downloads (6 months)1 ( #292,059 of 1,101,579 )
How can I increase my downloads?