Mutations, developmental instability, and the red queen

Behavioral and Brain Sciences 29 (4):412-413 (2006)
Abstract
We address two points. First, one must explain how different, rare mutations ultimately lead to common psychopathological conditions. The developmental instability model offers one solution. Second, Keller & Miller (K&M) perhaps miss the major processes other than variation fueled by rare deleterious mutations that account for interesting genetic variation in psychopathology, particularly when single alleles have non-negligible effects: Red Queen processes. (Published Online November 9 2006).
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