David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
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Biology and Philosophy 14 (3):349-373 (1999)
The paper argues for a pragmatic account of genetic explanation. This is to say that when a disease or other trait is termed genetic, the reasons for singling out genes as causes over other, also necessary, genetic and nongenetic conditions are not wholly theoretical but include pragmatic dimensions. Whether the explanation is the presence of a trait in an individual or differences in a trait among individuals, genetic explanations are context-dependent in three ways: they are relative to a causal background of genetic and nongenetic factors; they are relative to a population; and they are relative to the present state of knowledge. Criteria like causal priority, nonstandardness, and causal efficacy that purport to distinguish objectively between genetic causes and nongenetic conditions either incorporate pragmatic elements or fail for other reasons. When the pragmatic dimensions of genetic explanations are recognized, we come to understand the current phenomenon of geneticization to be a reflection of increased technological capacities to manipulate genes in the laboratory, and potentially the clinic, rather than theoretical progress in understanding how diseases and other traits arise. This calls into question the value of the search for theoretical definitions of designations like genetic disease or genetic susceptibility as directives for action.
|Keywords||cause-condition distinction genetic trait geneticization pragmatic|
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Citations of this work BETA
Karola Stotz, Paul E. Griffiths & Rob Knight (2004). How Biologists Conceptualize Genes: An Empirical Study. Studies in History and Philosophy of Science Part C 35 (4):647-673.
Monika Piotrowska (2013). From Humanized Mice to Human Disease: Guiding Extrapolation From Model to Target. Biology and Philosophy 28 (3):439-455.
Christopher J. Austin (2015). The Dispositional Genome: Primus Inter Pares. Biology and Philosophy 30 (2):227-246.
Françoise Baylis & Jason Scott Robert (2004). The Inevitability of Genetic Enhancement Technologies. Bioethics 18 (1):1–26.
Ulrich E. Stegmann (2012). Varieties of Parity. Biology and Philosophy 27 (6):903-918.
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