Graduate studies at Western
Biology and Philosophy 27 (6):785-810 (2012)
|Abstract||The aim of this paper is to assess the relevance of somatic evolution by natural selection to our understanding of cancer development. I do so in two steps. In the first part of the paper, I ask to what extent cancer cells meet the formal requirements for evolution by natural selection, relying on Godfrey-Smith’s (2009) framework of Darwinian populations. I argue that although they meet the minimal requirements for natural selection, cancer cells are not paradigmatic Darwinian populations. In the second part of the paper, I examine the most important examples of adaptation in cancer cells. I argue that they are not significant accumulations of evolutionary changes, and that as a consequence natural selection plays a lesser role in their explanation. Their explanation, I argue, is best sought in the previously existing wiring of the healthy cells.|
|Keywords||cancer adaptation natural selection explanation Darwinian populations|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
Denis M. Walsh (2003). Fit and Diversity: Explaining Adaptive Evolution. Philosophy of Science 70 (2):280-301.
Armando Aranda-Anzaldo (2001). Cancer Development and Progression: A Non-Adaptive Process Driven by Genetic Drift. Acta Biotheoretica 49 (2).
Anya Plutynski (2010). Review of Godfrey-Smith's Darwinian Populations and Natural Selection. [REVIEW] Philosophical Books 51 (2):83-101.
David Queller (2011). A Gene's Eye View of Darwinian Populations. Biology and Philosophy 26 (6):905-913.
Joeri Witteveen (2009). Darwinism About Darwinism. [REVIEW] Biological Theory 4 (2):207-213.
Roy Douglas Pearson (1981). Tumourigenesis: The Subterfuge of Selection. Acta Biotheoretica 30 (3).
Matt Gers (2012). Overqualified: Generative Replicators as Darwinian Reproducers. Biology and Philosophy 27 (4):595-605.
Maximiliano Martínez (2011). Natural Selection and Multi-Level Causation. Philosophy and Theory in Biology 3.
Rebecca Dresser (2011). Bioethics and Cancer: When the Professional Becomes Personal. Hastings Center Report 41 (6):14-18.
Jerry Fodor (2008). Against Darwinism. Mind and Language 23 (1):1–24.
Dominik Wodarz (2006). Somatic Evolution of Cells and the Development of Cancer. Biological Theory 1 (2):119-122.
T. Pradeu (2011). Darwinian Populations and Natural Selection, by Peter Godfrey-Smith. Mind 120 (479):863-870.
Added to index2012-08-04
Total downloads49 ( #25,884 of 739,400 )
Recent downloads (6 months)12 ( #9,672 of 739,400 )
How can I increase my downloads?