David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jonathan Jenkins Ichikawa
Jack Alan Reynolds
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Biology and Philosophy 27 (6):785-810 (2012)
The aim of this paper is to assess the relevance of somatic evolution by natural selection to our understanding of cancer development. I do so in two steps. In the first part of the paper, I ask to what extent cancer cells meet the formal requirements for evolution by natural selection, relying on Godfrey-Smith’s (2009) framework of Darwinian populations. I argue that although they meet the minimal requirements for natural selection, cancer cells are not paradigmatic Darwinian populations. In the second part of the paper, I examine the most important examples of adaptation in cancer cells. I argue that they are not significant accumulations of evolutionary changes, and that as a consequence natural selection plays a lesser role in their explanation. Their explanation, I argue, is best sought in the previously existing wiring of the healthy cells.
|Keywords||cancer adaptation natural selection explanation Darwinian populations|
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References found in this work BETA
S. J. Gould & R. C. Lewontin (1994). The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme. In E. Sober (ed.), Conceptual Issues in Evolutionary Biology. The MIT Press. Bradford Books 73-90.
C. Kenneth Waters (2007). Causes That Make a Difference. Journal of Philosophy 104 (11):551-579.
Frédéric Bouchard (2008). Causal Processes, Fitness, and the Differential Persistence of Lineages. Philosophy of Science 75 (5):560-570.
David L. Hull, Rodney E. Langman & Sigrid S. Glenn (2001). A General Account of Selection: Biology, Immunology, and Behavior. Behavioral and Brain Sciences 24 (3):511-528.
Citations of this work BETA
Sara Green, Arnon Levy & William Bechtel (2015). Design Sans Adaptation. European Journal for Philosophy of Science 5 (1):15-29.
Alessandro Blasimme, Paolo Maugeri & Pierre-Luc Germain (2013). What Mechanisms Can’T Do: Explanatory Frameworks and the Function of the P53 Gene in Molecular Oncology. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (3):374-384.
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