Complex genetic causation of human disease: Critiques of and rationales for heritability and path analysis
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Theoretical Medicine and Bioethics 10 (2) (1989)
This paper examines some criticisms that have been made of two standard genetic methodologies: heritability and path analysis. I conclude that the criticisms should be taken seriously, concerning both the accuracy of heritability measures and their significance. In light of the fact that such studies remain prominent in the literature, I consider what possible rationale they can retain consistent with these criticisms. In particular, I consider (1) a role in the identification of high-risk individuals and (2) a heuristic role in the planning of research strategy.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Omri Tal (2009). From Heritability to Probability. Biology and Philosophy 24 (1):81-105.
Omri Tal (forthcoming). The Impact of Gene–Environment Interaction and Correlation on the Interpretation of Heritability. Acta Biotheoretica.
Neven Sesardic (1993). Heritability and Causality. Philosophy of Science 60 (3):396-418.
Peter Taylor (2006). Heritability and Heterogeneity: The Irrelevance of Heritability in Explaining Differences Between Means for Different Human Groups or Generations. Biological Theory 1 (4):392-401.
Samir Okasha (2003). The Concept of Group Heritability. Biology and Philosophy 18 (3):445-461.
Ainsley Newson (2004). The Nature and Significance of Behavioural Genetic Information. Theoretical Medicine and Bioethics 25 (2):89-111.
Peter Taylor (2006). Heritability and Heterogeneity: The Limited Relevance of Heritability in Investigating Genetic and Environmental Factors. Biological Theory 1 (2):150-164.
Gry Oftedal (2005). Heritability and Genetic Causation. Philosophy of Science 72 (5):699-709.
Neven Sesardic (2003). Heritability and Indirect Causation. Philosophy of Science 70 (5):1002-1014.
Sidney J. Segalowitz (1999). Why Twin Studies Really Don't Tell Us Much About Human Heritability. Behavioral and Brain Sciences 22 (5):904-905.
Added to index2009-01-28
Total downloads8 ( #167,561 of 1,098,129 )
Recent downloads (6 months)1 ( #283,807 of 1,098,129 )
How can I increase my downloads?