Relative Versus Absolute Standards for Everyday Risk in Adolescent HIV Prevention Trials: Expanding the Debate

American Journal of Bioethics 11 (6):5 - 13 (2011)
Abstract
The concept of minimal risk has been used to regulate and limit participation by adolescents in clinical trials. It can be understood as setting an absolute standard of what risks are considered minimal or it can be interpreted as relative to the actual risks faced by members of the host community for the trial. While commentators have almost universally opposed a relative interpretation of the environmental risks faced by potential adolescent trial participants, we argue that the ethical concerns against the relative standard may not be as convincing as these commentators believe. Our aim is to present the case for a relative standard of environmental risk in order to open a debate on this subject. We conclude by discussing how a relative standard of environmental risk could be defended in the specific case of an HIV vaccine trial among adolescents in South Africa
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    References found in this work BETA
    Loretta M. Kopelman (2000). Children as Research Subjects: A Dilemma. Journal of Medicine and Philosophy 25 (6):723-744.

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    Citations of this work BETA
    David B. Resnik (2011). Reopening Old Divisions. American Journal of Bioethics 11 (6):19 - 21.

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    David Wendler (2004). Risk Standards for Pediatric Research: Rethinking The. Kennedy Institute of Ethics Journal 14 (2):187-198.
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