Dynamic Simulation of Mitochondrial Respiration and Oxidative Phosphorylation: Comparison with Experimental Results
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 56 (1-2):157-172 (2008)
Hypoxia hampers ATP production and threatens cell survival. Since cellular energetics tightly controls cell responses and fate, ATP levels and dynamics are of utmost importance. An integrated mathematical model of ATP synthesis by the mitochondrial oxidative phosphorylation/electron transfer chain system has been recently published :e36, 2005). This model was validated under static conditions. To evaluate its performance under dynamical situations, we implemented and simulated it . Inner membrane potential and [NADH] were used as indicators of mitochondrial function. Root mean squared error was used to compare simulations and experiments :39155–39165, 2003). Steady-state experimental data were reproduced within 2–6%. Model dynamics were evaluated under: baseline, activation of NADH production, addition of ADP, addition of inorganic phosphate, oxygen exhaustion. In all phases, except the last one, ΔΨ and [NADH] as well as oxygen consumption, were reproduced . Under anoxia, simulated ΔΨ markedly depolarized . In conclusion, the model reproduces dynamic data as long as oxygen is present. Anticipated improvement by the inclusion of ATP consumption and explicit Krebs cycle are under evaluation
|Keywords||Philosophy Evolutionary Biology Philosophy of Biology|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Bruce H. Weber & John N. Prebble (2006). An Issue of Originality and Priority: The Correspondence and Theories of Oxidative Phosphorylation of Peter Mitchell and Robert J.P. Williams, 1961-1980. [REVIEW] Journal of the History of Biology 39 (1):125 - 163.
I. Ferrenq, L. Tranqui, B. Vailhé, P. Y. Gumery & P. Tracqui (1997). Modelling Biological Gel Contraction by Cells: Mechanocellular Formulation and Cell Traction Force Quantification. Acta Biotheoretica 45 (3-4):267-293.
Laurent Buffat & Jean-Yves Mary (1992). Automatic Search for Model to Simulate the Differentiation of T Lymphocytes Within the Thymus. Acta Biotheoretica 40 (2-3):205-220.
Christian Vauge, Thérèse-Marie Mignot, Brigitte Paris, Michelle Breuiller-Fouché, Charles Chapron, Michel Attoui & Françoise Ferré (2003). A Mathematical Model for the Spontaneous Contractions of the Isolated Uterine Smooth Muscle From Patients Receiving Progestin Treatment. Acta Biotheoretica 51 (1):19-34.
Terkia Medkour, Frank Ferrone, Frédéric Galactéros & Patrick Hannaert (2008). The Double Nucleation Model for Sickle Cell Haemoglobin Polymerization: Full Integration and Comparison with Experimental Data. Acta Biotheoretica 56 (1-2):103-122.
Christine Reder (2001). Mutated mtDNA Distribution in Exponentially Growing Cell Cultures and How the Segregation Rate is Increased by the Mitochondrial Compartments. Acta Biotheoretica 49 (4):235-245.
Peter D. Sozou & Thomas B. L. Kirkwood, A Stochastic Model of Cell Replicative Senescence Based on Telomere Shortening, Oxidative Stress, and Somatic Mutations in Nuclear and Mitochondrial DNA.
Agnès Aubert, Robert Costalat & Romain Valabrègue (2001). Modelling of the Coupling Between Brain Electrical Activity and Metabolism. Acta Biotheoretica 49 (4):301-326.
Andrzej Kasperski (2008). Modelling of Cells Bioenergetics. Acta Biotheoretica 56 (3):233-247.
Added to index2009-01-28
Total downloads8 ( #241,511 of 1,696,550 )
Recent downloads (6 months)5 ( #113,990 of 1,696,550 )
How can I increase my downloads?