How Good Is “Good Enough”? The Case for Varying Standards of Evidence According to Need for New Interventions in HIV Prevention
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
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American Journal of Bioethics 12 (6):21-30 (2012)
In 2010, randomized controlled trials (RCTs) of two different biomedical strategies to prevent HIV infection had positive findings. However, despite ongoing very high levels of HIV infection in some countries and population groups, it has been made clear by regulatory authorities that the evidence remains insufficient to support either product being made available outside of research contexts in the developing world for at least two years. In addition, prevention trials in endemic areas will continue to test new interventions against placebo. But the judgments of evidentiary standards are never value-neutral. Using the recent trials and their contexts as case studies, we examine the basis for these decisions, which will potentially delay access to scientific innovation to the people who are most urgently in need of it
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Citations of this work BETA
Bridget Haire (2015). It’s Time: The Case for PrEP as an Active Comparator in HIV Biomedical Prevention Trials. Journal of Bioethical Inquiry 12 (2):239-249.
Bridget Haire & John M. Kaldor (2013). Ethics of ARV Based Prevention: Treatment‐as‐Prevention and PrEP. Developing World Bioethics 13 (2):63-69.
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