How Good Is “Good Enough”? The Case for Varying Standards of Evidence According to Need for New Interventions in HIV Prevention
Graduate studies at Western
American Journal of Bioethics 12 (6):21-30 (2012)
|Abstract||In 2010, randomized controlled trials (RCTs) of two different biomedical strategies to prevent HIV infection had positive findings. However, despite ongoing very high levels of HIV infection in some countries and population groups, it has been made clear by regulatory authorities that the evidence remains insufficient to support either product being made available outside of research contexts in the developing world for at least two years. In addition, prevention trials in endemic areas will continue to test new interventions against placebo. But the judgments of evidentiary standards are never value-neutral. Using the recent trials and their contexts as case studies, we examine the basis for these decisions, which will potentially delay access to scientific innovation to the people who are most urgently in need of it|
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
Bridget G. Haire (2011). Because We Can: Clashes of Perspective Over Researcher Obligation in the Failed Prep Trials. Developing World Bioethics 11 (2):63-74.
Melissa Stobie & Catherine Slack (2010). Treatment Needs in Hiv Prevention Trials: Using Beneficence to Clarify Sponsor-Investigator Responsibilities. Developing World Bioethics 10 (3):150-157.
R. Macklin (2010). Intertwining Biomedical Research and Public Health in HIV Microbicide Research. Public Health Ethics 3 (3):199-209.
Charles Weijer & Guy LeBlanc, Revisiting the Ethics of HIV Prevention Research in Developing Countries.
B. M. Meier, K. N. Brugh & Y. Halima (2012). Conceptualizing a Human Right to Prevention in Global HIV/AIDS Policy. Public Health Ethics 5 (3):263-282.
S. Philpott, K. West Slevin, K. Shapiro & L. Heise (2010). Impact of Donor-Imposed Requirements and Restrictions on Standards of Prevention and Access to Care and Treatment in HIV Prevention Trials. Public Health Ethics 3 (3):220-228.
Joseph-Matthew Mfutso-Bengo, Eva-Maria Mfutso-Bengo & Francis Masiye (2008). Ethical Aspects of Hiv/Aids Prevention Strategies and Control in Malawi. Theoretical Medicine and Bioethics 29 (5):349-356.
Udo Schuklenk (2007). HIV Vaccine Trials: Reconsidering the Therapeutic Misconception and the Question of What Constitutes Trial Related Injuries. Developing World Bioethics 7 (3).
Jennifer Koen, Zaynab Essack, Catherine Slack, Graham Lindegger & Peter A. Newman (2012). 'It Looks Like You Just Want Them When Things Get Rough': Civil Society Perspectives on Negative Trial Results and Stakeholder Engagement in HIV Prevention Trials. Developing World Bioethics 12 (3):138-148.
Timothy F. Murphy (1994). Health Care Workers with Hiv and a Patient's Right to Know. Journal of Medicine and Philosophy 19 (6):553-569.
Charles Weijer & Guy J. Leblanc (2006). The Balm of Gilead: Is the Provision of Treatment to Those Who Seroconvert in HIV Prevention Trials a Matter of Moral Obligation or Moral Negotiation? Journal of Law, Medicine and Ethics 34 (4):793-808.
Keymanthri Moodley (2007). Microbicide Research in Developing Countries: Have We Given the Ethical Concerns Due Consideration? BMC Medical Ethics 8 (1):1-7.
Christine Grady (1994). Hiv Preventive Vaccine Research: Selected Ethical Issues. Journal of Medicine and Philosophy 19 (6):595-612.
Yanguang Wang (2000). A Strategy of Clinical Tolerance for the Prevention of Hiv and Aids in China. Journal of Medicine and Philosophy 25 (1):48 – 61.
Added to index2012-06-01
Total downloads4 ( #189,757 of 749,219 )
Recent downloads (6 months)1 ( #62,892 of 749,219 )
How can I increase my downloads?