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- Stuart Hameroff, Search for Quantum and Classical Modes of Information Processing in Microtubules: Implications for “the Living State”.Dynamical activities within living eukaryotic cells are organized by microtubules, main structural components of the cytoskeleton and cylindrical polymers of the protein tubulin. Evidence and theoretical models suggest that states of tubulin may play the role of “bits” in classical microtubule computational automata. The advent of quantum information devices, key roles played by quantum processes in protein dynamics, and coherent ordering in the cell cytoplasm further suggest that microtubules may function as quantum computational devices, and that mesoscopic and macroscopic quantum states are characteristic of living systems. In this paper new results from molecular dynamics simulation based on recently obtained atomic structure of tubulin are presented which provide support for classical and quantum modes of microtubule information processing.
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The original development of the formalism of quantum mechanics involved the study of isolated quantum systems in pure states. Such systems fail to capture important aspects of the warm, wet, and noisy physical world which can better be modelled by quantum statistical mechanics and local quantum field theory using mixed states of continuous systems. In this context, we need to be able to compute quantum probabilities given only partial information. Specifically, suppose that B is a set of operators. This set need not be a von Neumann algebra. Simple axioms are proposed which allow us to identify a function which can be interpreted as the probability, per unit trial of the information specified by B, of observing the (mixed) state of the world restricted to B to be σ when we are given ρ – the restriction to B of a prior state. This probability generalizes the idea of a mixed state (ρ) as being a sum of terms (σ) weighted by probabilities. The unique function satisfying the axioms can be defined in terms of the relative entropy. The analogous inference problem in classical probability would be a situation where we have some information about the prior distribution, but not enough to determine it uniquely. In such a situation in quantum theory, because only what we observe should be taken to be specified, it is not appropriate to assume the existence of a fixed, definite, unknown prior state, beyond the set B about which we have information. The theory was developed for the purposes of a fairly radical attack on the interpretation of quantum theory, involving many-worlds ideas and the abstract characterization of observers as finite information-processing structures, but deals with quantum inference problems of broad generality.
In this paper we show how recent concepts from Dynamic Logic, and in particular from Dynamic Epistemic logic, can be used to model and interpret quantum behavior. Our main thesis is that all the non-classical properties of quantum systems are explainable in terms of the non-classical flow of quantum information. We give a logical analysis of quantum measurements (formalized using modal operators) as triggers for quantum information flow, and we compare them with other logical operators previously used to model various forms of classical information flow: the “test” operator from Dynamic Logic, the “announcement” operator from Dynamic Epistemic Logic and the “revision” operator from Belief Revision theory. The main points stressed in our investigation are the following: (1) The perspective and the techniques of “logical dynamics” are useful for understanding quantum information flow. (2) Quantum mechanics does not require any modification of the classical laws of “static” propositional logic, but only a non-classical dynamics of information. (3) The main such non-classical feature is that, in a quantum world, all information-gathering actions have some ontic side-effects. (4) This ontic impact can affect in its turn the flow of information, leading to non-classical epistemic side-effects (e.g. a type of non-monotonicity) and to states of “objectively imperfect information”. (5) Moreover, the ontic impact is non-local: an information-gathering action on one part of a quantum system can have ontic side-effects on other, far-away parts of the system.
Some physicists seem to believe that quantum information theory requires a new concept of information (Jozsa, 1998, Quantum information and its properties. In: Hoi-Kwong Lo, S. Popescu, T. Spiller (Eds.), Introduction to Quantum Computation and Information, World Scientific, Singapore, (pp. 49-75); Deutsch & Hayden, 1999, Information flow in entangled quantum subsystems, preprint quant-ph/9906007). I will argue that no new concept is necessary. Shannon's concept of information is sufficient for quantum information theory. Properties that are cited to contrast quantum information and classical information (i.e., Shannon information) actually point to differences in our ability to manipulate, access, and transfer information depending on whether quantum systems, opposed to classical systems, are used in a communication system. I also demonstrate that conceptually puzzling phenomena in quantum information theory, such as dense coding, teleportation, and Schumacher coding, all of which are cited as evidence that a new concept of information is required, do not have to be regarded as such.
Proposals for quantum computation rely on superposed states implementing multiple computations simultaneously, in parallel, according to quantum linear superposition (e.g., Benioff, 1982; Feynman, 1986; Deutsch, 1985, Deutsch and Josza, 1992). In principle, quantum computation is capable of specific applications beyond the reach of classical computing (e.g., Shor, 1994). A number of technological systems aimed at realizing these proposals have been suggested and are being evaluated as possible substrates for quantum computers (e.g. trapped ions, electron spins, quantum dots, nuclear spins, etc., see Table 1; Bennett, 1995; and Barenco, 1995). The main obstacle to realization of quantum computation is the problem of interfacing to the system (input, output) while also protecting the quantum state from environmental decoherence. If this problem can be overcome, then present day classical computers may evolve to quantum computers.
Many recent results suggest that quantum theory is about information, and that quantum theory is best understood as arising from principles concerning information and information processing. At the same time, by far the simplest version of quantum mechanics, Bohmian mechanics, is concerned, not with information but with the behavior of an objective microscopic reality given by particles and their positions. What I would like to do here is to examine whether, and to what extent, the importance of information, observation, and the like in quantum theory can be understood from a Bohmian perspective. I would like to explore the hypothesis that the idea that information plays a special role in physics naturally emerges in a Bohmian universe.
Using the Gödel Incompleteness Result for leverage, Roger Penrose has argued that the mechanism for consciousness involves quantum gravitational phenomena, acting through microtubules in neurons. We show that this hypothesis is implausible. First, the Gödel Result does not imply that human thought is in fact non algorithmic. Second, whether or not non algorithmic quantum gravitational phenomena actually exist, and if they did how that could conceivably implicate microtubules, and if microtubules were involved, how that could conceivably implicate consciousness, is entirely speculative. Third, cytoplasmic ions such as calcium and sodium are almost certainly present in the microtubule pore, barring the quantum mechanical effects Penrose envisages. Finally, physiological evidence indicates that consciousness does not directly depend on microtubule properties in any case, rendering doubtful any theory according to which consciousness is generated in the microtubules.
Using the Gödel Incompleteness Result for leverage, Roger Penrose has argued that the mechanism for consciousness involves quantum gravitational phenomena, acting through microtubules in neurons. We show that this hypothesis is implausible. First, the Gödel Result does not imply that human thought is in fact non algorithmic. Second, whether or not non algorithmic quantum gravitational phenomena actually exist, and if they did how that could conceivably implicate microtubules, and if microtubules were involved, how that could conceivably implicate consciousness, is entirely speculative. Third, cytoplasmic ions such as calcium and sodium are almost certainly present in the microtubule pore, barring the quantum mechanical effects Penrose envisages. Finally, physiological evidence indicates that consciousness does not directly depend on microtubule properties in any case, rendering doubtful any theory according to which consciousness is generated in the microtubules.
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There have been many claims that quantum mechanics plays a key role in the origin and/or operation of biological organisms, beyond merely providing the basis for the shapes and sizes of biological molecules and their chemical affinities. These range from Schr¨odinger’s suggestion that quantum fluctuations produce mutations, to Hameroff and Penrose’s conjecture that quantum coherence in microtubules is linked to consciousness. I review some of these claims in this paper, and discuss the serious problem of decoherence. I advance some further conjectures about quantum information processing in bio-systems. Some possible experiments are suggested. © 2004 Elsevier Ireland Ltd. All rights reserved.
Features of consciousness difficult to understand in terms of conventional neuroscience have evoked application of quantum theory, which describes the fundamental behavior of matter and energy. In this paper we propose that aspects of quantum theory (e.g. quantum coherence) and of a newly proposed physical phenomenon of quantum wave function "self-collapse"(objective reduction: OR -Penrose, 1994) are essential for consciousness, and occur in cytoskeletal microtubules and other structures within each of the brain's neurons. The particular characteristics of microtubules suitable for quantum effects include their crystal-like lattice structure, hollow inner core, organization of cell function and capacity for information processing. We envisage that conformational states of microtubule subunits (tubulins) are coupled to internal quantum events, and cooperatively interact (compute) with other tubulins. We further assume that macroscopic coherent superposition of quantum-coupled tubulin conformational states occurs throughout significant brain volumes and provides the global binding essential to consciousness. We equate the emergence of the microtubule quantum coherence with pre-conscious processing which grows (for up to 500 milliseconds) until the mass-energy difference among the separated states of tubulins reaches a threshold related to quantum gravity. According to the arguments for OR put forth in Penrose (1994), superpositioned states each have their own space-time geometries. When the degree of coherent massenergy difference leads to sufficient separation of space-time geometry, the system must choose and decay (reduce, collapse) to a single universe state. In this way, a transient superposition of slightly differing space-time geometries persists until an abrupt quantum classical reduction occurs. Unlike the random, "subjective reduction"(SR, or R) of standard quantum theory caused by observation or environmental entanglement, the OR we propose in microtubules is a self-collapse and it results in particular patterns of microtubule-tubulin conformational states that regulate neuronal activities including synaptic functions. Possibilities and probabilities for post-reduction tubulin states are influenced by factors including attachments of microtubule-associated proteins (MAPs) acting as "nodes"which tune and "orchestrate"the quantum oscillations..
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Features of consciousness difficult to understand in terms of conventional neuroscience have evoked application of quantum theory, which describes the fundamental behavior of matter and energy. In this paper we propose that aspects of quantum theory (e.g. quantum coherence) and of a newly proposed physical phenomenon of quantum wave function "self-collapse"(objective reduction: OR -Penrose, 1994) are essential for consciousness, and occur in cytoskeletal microtubules and other structures within each of the brain's neurons. The particular characteristics of microtubules suitable for quantum effects include their crystal-like lattice structure, hollow inner core, organization of cell function and capacity for information processing. We envisage that conformational states of microtubule subunits (tubulins) are coupled to internal quantum events, and cooperatively interact (compute) with other tubulins. We further assume that macroscopic coherent superposition of quantum-coupled tubulin conformational states occurs throughout significant brain volumes and provides the global binding essential to consciousness. We equate the emergence of the microtubule quantum coherence with pre-conscious processing which grows (for up to 500 milliseconds) until the mass-energy difference among the separated states of tubulins reaches a threshold related to quantum gravity. According to the arguments for OR put forth in Penrose (1994), superpositioned states each have their own space-time geometries. When the degree of coherent mass-energy difference leads to sufficient separation of space-time geometry, the system must choose and decay (reduce, collapse) to a single universe state. In this way, a transient superposition of slightly differing space-time geometries persists until an abrupt quantum classical reduction occurs. Unlike the random, "subjective reduction"( SR, or R) of standard quantum theory caused by observation or environmental entanglement, the OR we propose in microtubules is a self-collapse and it results in particular patterns of microtubule-tubulin conformational states that regulate neuronal activities including synaptic functions.
Discussion of Stuart Hameroff, Search for quantum and classical modes of information processing in microtubules: Implications for “the living state”
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